Results 261 to 270 of about 1,116,885 (306)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effects of Chinese cervical fixed-point rotation manipulation on heart rate variability in patients with sympathetic cervical spondylosis based on the theory of biomechanical equilibrium: a study protocol for a randomized controlled trial. [PDF]

Front Neurol
Zeng X, Zheng S, Xie Y, Ma H, Zuo J, Fan Z, Qiu P.   +6 more
europepmc   +1 more source

<i>proRate</i>: an R package to infer gene transcription rates with a novel least sum of squares method. [PDF]

NAR Genom Bioinform
Liu Y, Alakwaa F.
europepmc   +1 more source

From fixed time points to personalized care: rethinking stroke risk management in atrial fibrillation patients. [PDF]

Europace
Mei DA, Imberti JF, Boriani G.
europepmc   +1 more source

Efficacy of lateral retinacular release versus no release in total knee arthroplasty: a systematic review and meta-analysis. [PDF]

Eur J Med Res
Zou Y, Cao C, Sun X, Zhang G.
europepmc   +1 more source

Patient-Physician Messaging by Race, Ethnicity, Insurance Type, and Preferred Language.

JAMA Netw Open
Rotenstein LS, Hardy B, Tang M, Steitz B, Turer RW, Alsentzer E, Barnett ML.   +6 more
europepmc   +1 more source

A temporal hierarchy determines epigenetic aging

Ciarchi M, Simons BD, Rulands S.
europepmc   +1 more source

Reconstructing Waddington's Landscape from Data

Cislo DJ, Delás MJ, Briscoe J, Siggia ED.   +3 more
europepmc   +1 more source