Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
A Cross-Sectional Survey of Orthodontic Retention Practices and Opinions Among General Dental Practitioners in Australia. [PDF]
Meade MJ, Dreyer C.
europepmc +1 more source
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Spontaneous Resolution of Mandibular Incisor Gingival Recession Following Orthodontic Torque Correction With Fixed Appliances: A Case Report. [PDF]
Drissi Lahsini M +3 more
europepmc +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Open Bite With Short Root Anomaly: A Case Report. [PDF]
Alwadei S.
europepmc +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Bone Preservation for Replacement of Lateral Incisors: A Case Report. [PDF]
Laino L, Ciarlantini R, Wertheimer M.
europepmc +1 more source
Integration of Artificial Intelligence in Designing Removable Partial Dentures. [PDF]
Alageel O.
europepmc +1 more source
A Randomised Controlled Trial Comparing Thermoformed and 3D-Printed Retainers in Young Adults: Evaluation of Post-treatment Stability and Patient Satisfaction. [PDF]
Boo HS +4 more
europepmc +1 more source

