Results 181 to 190 of about 328,735 (192)

Using skin biopsies to measure target occupancy of anti-fibrotic molecules: assay development and application for zampilimab in a primate model of chronic kidney disease and in healthy human volunteers. [PDF]

BMC Nephrol
Huang L, Bowcutt R, Bigley A, Ogg G, Schmidt T, Johnston GI, Johnson TS.   +6 more
europepmc   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

FLARE: A Flow Cytometry-Based Fluorescent Assay for Measuring HSV-1 Nuclear Egress. [PDF]

Bio Protoc
Dai B, Polack L, Moores S, Calderon-Zavala AC, Heldwein EE.   +4 more
europepmc   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

Mature tertiary lymphoid structures in pilonidal sinus disease. [PDF]

JID Innov
Gupta R, Suresh RR, Roberson JL, Lee M, Maguire LH, Fang V.   +5 more
europepmc   +1 more source

Ca₁₃Mab-17, a Novel Anti-Cadherin-13 Monoclonal Antibody for Versatile Applications. [PDF]

Antibodies (Basel)
Shimizu K, Suzuki H, Kaneko MK, Kato Y.
europepmc   +1 more source

Cardiovascular β-Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue. [PDF]

Compr Physiol
Elsaid B, Kopaliani I, Zatschler B, Seif A, Speier S, Deussen A.   +5 more
europepmc   +1 more source

The PDE5 inhibitor vardenafil enhances glutamatergic transmission through amyloid-beta and cellular prion protein. [PDF]

Neurotherapeutics
Kafi MAA, Passalacqua M, Villa V, Thellung S, Corsaro A, Grimaldi R, Spatola E, Florio T, Baldelli P, Ricciarelli R.   +9 more
europepmc   +1 more source

Protocol to study murine ovarian elasticity and composition in situ by integrating quantitative micro-elastography with light microscopy. [PDF]

STAR Protoc
Jaeschke A, Hepburn MS, Mowla A, Eckert H, Kennedy BF, Chan CJ.   +5 more
europepmc   +1 more source

Comparative Analysis of Glycan Composition in Therapeutic Antibodies via Glycan Profiling and Intact Mass Analysis. [PDF]

Molecules
Chun YS, Lee JB, Seomun S, Park S, Na JH, Ko BJ.   +5 more
europepmc   +1 more source