Results 241 to 250 of about 338,471 (290)

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains. [PDF]

EMBO J
Reinders M, Kravic B, Gahlot P, Koska S, van den Boom J, Schulze N, Levantovsky S, Kleine S, Kaiser M, Kulathu Y, Behrends C, Meyer H.   +11 more
europepmc   +1 more source

Integrin β4‐Enriched Small Extracellular Vesicle as Drug Delivery Vehicle for Targeting Pulmonary Metastasis of Hepatocellular Carcinoma

Advanced Healthcare Materials, EarlyView.
The expression of integrin β4 (ITGβ4) on small extracellular vesicle (sEV) correlates with lung‐tropism. Enrichment of ITGβ4 on sEVs enhances their lung‐targeting ability. The sEVs loaded with doxorubicin exhibit superior therapeutic efficacy in a lung metastasis mouse model.
Tung Him Ng, Aijun Liang, Maximus CF Yeung, Sze Keong Tey, Kam‐Leung Siu, Sin‐Yee Fung, Dong‐Yan Jin, Judy Wai Ping Yam   +7 more
wiley   +1 more source

Myomedin variants developed for in vitro PD-L1 diagnostics in tissue samples of non-small cell lung carcinoma patients. [PDF]

J Transl Med
Petroková H, Mierzwicka JM, Chakraborty P, Rašková Kafková L, Vaculová J, Škarda J, Fischer O, Kosztyu P, Kuchař M, Raška M, Malý P.   +10 more
europepmc   +1 more source

A Robust Heparin‐Mimicking Polyglycerol‐Based Coating for Blood‐Contacting Devices with Long‐Term Hemocompatibility and Preliminary Anti‐Inflammatory Properties

Advanced Healthcare Materials, EarlyView.
A robust heparin‐mimicking coating based on sulfated polyglycerol is constructed via layer‐by‐layer assembly on bloodcontacting surfaces. The coating exhibits long‐term anticoagulant and anti‐inflammatory properties by resisting protein adsorption, preventing platelet activation, and suppressing immune responses, offering a promising strategy for ...
Kunpeng Liu, Philip Nickl, Jun Feng, Rainer Haag   +3 more
wiley   +1 more source

Translational Extracellular Matrix Spray‐Coating Approach for Large‐Scale Bioactive Surface Functionalization and Tissue Repair

Advanced Healthcare Materials, EarlyView.
A translational spray‐coating strategy that conformationally activates fibronectin and collagen via mechanical unfolding is presented. Microscale droplets enable uniform extracellular matrix (ECM) depositions on biomedical substrates and wound closure enhancement.
Albertus Ivan Brilian, Chaeeon Lim, Grant Lee, Sang Ho Lee, Ignasia Handipta Mahardika, Seung‐Heon Yoo, Yejin Jo, Hayan Jeong, Bong‐Gun Ju, F. John Burpo, Giyoong Tae, Kwanwoo Shin   +11 more
wiley   +1 more source

Biocompatible PVDF Nanofibers with Embedded Magnetite Nanodiscs Enable Wireless Magnetoelectric Stimulation in Premotor Cortex

Advanced Healthcare Materials, EarlyView.
Flexible, biocompatible PVDF nanofibers embedded with magnetite nanodiscs enable wireless magnetoelectric neuromodulation. Shape anisotropy of the nanodiscs facilitates magnetostrictive strain transfer under alternating magnetic fields, allowing activation of neurons in vitro and behavioral modulation in vivo, without requiring rigid implants or ...
Lorenzo Signorelli, Anouk Wolters, Vicente Durán Toro, Jonas Englhard, Mahdieh Shojaei Baghini, Elif Koçar, Franziska Wasner, Nadine I. Goldenstein, Hadi Heidari, Julien Bachmann, Sarah Hescham, Danijela Gregurec   +11 more
wiley   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Protocol for the induction of human spinal motor neurons from human induced pluripotent stem cells for studying amyotrophic lateral sclerosis. [PDF]

STAR Protoc
Setsu S, Morimoto S, Nakamura S, Ozawa F, Okano H.   +4 more
europepmc   +1 more source

Biomimetic Scaffolds with Dual Gradients of Biological Effectors for Tendon‐to‐Bone Repair

Advanced Healthcare Materials, EarlyView.
The authors have developed a biomimetic scaffold with dual gradients through a diffusion‐driven method. The scaffold features funnel‐shaped microchannels for cell infiltration, while the dual gradients synergetically induce the graded differentiation of mesenchymal stem cells into osteoblasts, chondrocytes, and tenocytes, allowing for a seamless ...
Min Hao, Yidan Chen, Stavros Thomopoulos, Younan Xia   +3 more
wiley   +1 more source