Results 261 to 270 of about 338,471 (290)

Selective Lipolysis by Photoactivation of Chaperone‐Mediated Autophagy Using Adipocyte Membrane‐Coated Nanoparticle in Hydrogel

Advanced Materials, EarlyView.
Adipocyte membrane‐coated nanoparticles loaded with rosiglitazone in hydrogel offer an alternative approach to conventional obesity treatments. This system selectively targets adipocytes, inducing lipolysis by activating chaperone‐mediated autophagy through mild photothermal stimulation.
Jaehyun Choi, Junho Byun, Dongyoon Kim, Qiaoyun Li, Dongun Jin, Yeong‐jin Choi, Ho Sang Jung, Jaiwoo Lee, Yu‐Kyoung Oh   +8 more
wiley   +1 more source

Immune microenvironment and fibroblast subpopulation in diabetic wound healing. [PDF]

iScience
Gan J, Chen Y, Tang L, Dong H, Gao X, Huang Y, Pan Y, Hong J, Bai Z, Chen X, Lin Z, Zhu H.   +11 more
europepmc   +1 more source

Bi‐Functional Topospecific Nanoparticles to Promote Immune‐Tumor Cell Engagement as A New Immunotherapeutic Strategy

Advanced Materials, EarlyView.
A Janus‐engineered nanoplatform (J‐pHLIP‐PD1), featuring separate tumor‐ and immune‐targeting faces, bridges melanoma cells and cytotoxic T lymphocytes using toposelective pHLIP and anti‐PD‐1 presentation. This strategy elicits robust antitumor responses, promotes immunogenic tumor cell death, suppresses lung metastasis in vivo, and provides a modular,
Alba Ortuño‐Bernal, Sandra Clara‐Trujillo, Elena Lucena‐Sánchez, Francisco J. Hicke, Andrea Escudero, Sandra Pradana‐López, Nelia Jiménez‐Alduan, Paula Díez, Alba García‐Fernández, Ramón Martínez‐Máñez   +9 more
wiley   +1 more source

Vascularized and Perfusable Human Heart‐on‐a‐Chip Model Recapitulates Aspects of Myocardial Ischemia and Enables Analysis of Nanomedicine Delivery

Advanced Materials, EarlyView.
This novel 3D human ischemic heart‐on‐a‐chip, with perfusable vasculature directly interfaced with myocardial tissue, replicates key aspects of ischemic heart injury. It also demonstrates the targeted delivery and therapeutic efficacy of cardiac homing peptide‐conjugated liposomes, validating the platform for drug and nanomedicine screening in ...
Junyoung Kim, Xuening Zhang, Richard Wang, Adrian Najer, Qiao You Lau, Ana Cammack‐Najera, Jang Ah Kim, Yoo Kyung Kang, Ruoxiao Xie, Hyemin Kim, Kai Xie, Hyeonji Lim, Tae‐Eun Park, Jinmyoung Joo, Molly M. Stevens   +14 more
wiley   +1 more source

Isolation of a Monoclonal Human scFv Against Cytomegalovirus pp71 Antigen Using Yeast Display. [PDF]

Antibodies (Basel)
Aoki K, Yabe R, Ono S, Saeki M, Tanno Y, Tanno H.   +5 more
europepmc   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

The axonal ER couples translation and secretion machineries for local delivery of axonal transmembrane proteins to promote axonal development

Nguyen HH, Kersten N, Li CH, de Jong H, Arora T, Liolios T, Nguyen DTM, Bebelman MP, Altelaar M, Koppers M, Farías GG.   +10 more
europepmc   +1 more source

Patch2MAP combines patch-clamp electrophysiology with super-resolution structural and protein imaging in identified single neurons without genetic modification. [PDF]

Sci Rep
Vardalaki D, Pham TLD, Frosch MP, Cosgrove GR, Carter BS, Richardson M, Cash SS, Harnett MT.   +7 more
europepmc   +1 more source

Light‐Harvesting Nanomaterials Based on Dyes for Energy Transfer and Amplified Biosensing

Advanced Materials, EarlyView.
Light harvesting (LH) in plants inspires researchers to develop artificial LH nanomaterials. Here, LH nanomaterials based on organic dyes are reviewed, considering fundamental challenges on aggregation‐caused quenching, excitation energy transfer, and exciton migration length.
Andrey S. Klymchenko, Deep Sekhar Biswas, Pascal Didier   +2 more
wiley   +1 more source

Metabolite-enhanced normothermic machine perfusion improves kidney transplant viability. [PDF]

JCI Insight
Czogalla J, Hausmann F, Lagies S, Gies SE, Christiansen S, Kaiser N, Haas F, Okabayashi Y, Kylies D, Hofmann S, Franzin R, Sabra N, Bouari S, Fang Y, Ambagtsheer G, Edenhofer I, Chilla S, Mühlig AK, Zimmermann M, Wong MN, Yokoo T, Kretz O, Lindenmeyer M, Grahammer F, Hoogduijn MJ, de Bruin R, Kuehl M, Hänzelmann S, Kammerer B, Gesualdo L, Bonn S, Minnee RC, Huber TB, Puelles VG.   +33 more
europepmc   +1 more source