Results 221 to 230 of about 326,725 (317)

Prompt Framing Modulates Safety in Shoulder and Elbow Red-Flag Vignettes: A Large Language Model Study. [PDF]

Diagnostics (Basel)
Gökmen MY, Maden M, Zengin O.
europepmc   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

SQSTM1/p62 UFMylation Enhances Autophagic Clearance of Pathogenic Mutant Huntingtin. [PDF]

Int J Biol Sci
Wang X, Lv X, Jiang H, Zhu W, Cao L, Zhou L, Lin F, Deng R, Hu LF, Ma J, Li JB, Xu G.   +11 more
europepmc   +1 more source

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

Thermosensitivity of cellular translation restricts the growth of fission yeast at high temperatures. [PDF]

Commun Biol
Akikusa Y, Yamaguchi A, Funahashi Y, Tan ACW, Mahayot F, Naka T, Matsuo A, Nakase Y, Izawa S, Shiozaki K, Morozumi Y.   +10 more
europepmc   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Correction. [PDF]

Autophagy
europepmc   +1 more source

Domain-Specific Computational, Functional and Structural Methods Enable Interpretation of <i>BRCA1</i> BRCT Variants of Uncertain Significance. [PDF]

Curr Oncol
Torretto GC, Martin MD, Islam K, Archer NE, Feilotter HE, Davey SK.   +5 more
europepmc   +1 more source

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

SEL1L3 suppresses colorectal cancer cell growth and metastasis by preventing endoplasmic reticulum-associated degradation of STING. [PDF]

Cell Death Dis
Zhang H, Qian W, Li M, Zou X, Chen X, Miao K, Zhao M, Xu M, Dong J, Wang J, Peng H, Jia H, Hou Z.   +12 more
europepmc   +1 more source