Results 241 to 250 of about 147,336 (310)

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source

TRIM7 Inhibits Rabies Virus Replication by Promoting K48-Linked Ubiquitination and Degradation of RABV-M. [PDF]

Emerg Microbes Infect
He H, Liang W, Lin W, Wang Y, Su R, Wang Y, Huang S, Luo J, Guo X.   +8 more
europepmc   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Potato StRWA2 recruits the E3 ligase StSNIPER2 to destabilize NLRs and promote <i>Phytophthora infestans</i> infection. [PDF]

Hortic Res
Chen Z, He Z, Du J, Li Y, Niu S, Ma A, Chen Q, Guo H, Fan J, Ren M, Xu G, Dou D, Yang J, Jing M, Wang X.   +14 more
europepmc   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

The mouse-lethal H5N1 influenza virus carrying the PB2-384L/443R/460M characteristics acquired in avian hosts can effectively utilize human ANP32A/B proteins. [PDF]

Emerg Microbes Infect
Lin W, Deng G, Xing X, Shi J, Kong H, Liu L, Zeng X, Jiang L, Li C, Guan Y, Cui P, Chen H.   +11 more
europepmc   +1 more source

Conformational biosensors delineate endosomal G protein regulation by GPCRs. [PDF]

Nat Commun
Wysolmerski B, Fisher NM, Dates AN, Inoue A, Blythe EE, von Zastrow M.   +5 more
europepmc   +1 more source

Cellular sensor DAP5 decodes <i>Betacoronaviral</i> NSP5 to drive virus-induced senescence. [PDF]

Front Immunol
Lu Y, Xiao J, Wang J, Meng Z, Fan G, Zheng J, Yu M, Wang X, Li L.   +8 more
europepmc   +1 more source

Histone H2B-associated proteins: The Arabidopsis nucleolin 1 binds H2B and facilitates nucleosome disassembly via RNA-dependent mechanism. [PDF]

J Biol Chem
Yarra NK, Singiri JR, Agmon-Adler Z, Grandhi R, Sastya A, Novoplansky N, Grafi G.   +6 more
europepmc   +1 more source

Identification of a novel monoclonal antibody derived from the lumpy skin disease virus ORF123 that confers cross-binding and cross-neutralizing activity against Capripoxvirus members. [PDF]

Vet Res
Ren S, Wang F, Gao X, Gao X, Rehman ZU, Zhang H, Wang X, Qiu X, Shang Y, Yin X, Wan X, Chen H, Sun Y.   +12 more
europepmc   +1 more source