Advanced Science, EarlyView.Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu +7 more
wiley +1 more source
A Prospective Multicenter Study on the Evaluation of Frequency of Idiopathic Intracranial Hypertension in Korea. [PDF]
J Korean Med SciKim BS +13 more
europepmc +1 more source
AI‐Enhanced Vibrational Capsule for Minimally Invasive Detection of Abnormal Bowel Tissue
Advanced Science, EarlyView.A fully integrated vibration‐assisted capsule is presented for the minimally invasive detection of bowel lesions. The capsule incorporates a wireless sensor and an eccentric motor to probe tissue mechanics in situ. By coupling triaxial vibration signals with AI‐based classification and analytical modeling, the system enables early, non‐visual ...
Xizheng Fang +6 more
wiley +1 more source
AquaX: An enhanced and revised AquaMaps framework to model marine species distributions and biodiversity. [PDF]
PLoS OneReygondeau G +7 more
europepmc +1 more source
Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration
Advanced Science, EarlyView.Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman +5 more
wiley +1 more source
CtGAP 2.0: enhanced genome assembly, strain resolution, and phylogenomics for <i>Chlamydia trachomatis</i>. [PDF]
Microbiol Resour AnnouncOlagoke O, Read TD, Dean D.
europepmc +1 more source
Advanced Science, EarlyView.We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang +9 more
wiley +1 more source
Evaluating the use of red flags by online symptom checkers. [PDF]
BMC Health Serv ResSutaria S +5 more
europepmc +1 more source
Advanced Science, EarlyView.This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou +9 more
wiley +1 more source
Efficacy of a mobile app-based intervention to improve eating behaviours and lifestyle in infants of mothers with metabolic risk factors: study protocol of a randomised controlled trial. [PDF]
BMJ OpenChan D +7 more
europepmc +1 more source