Results 181 to 190 of about 37,257 (258)

Designing and Evaluating an Autoverification RCV-Based System for Thyroid Function Profiles. [PDF]

Diagnostics (Basel)
Gao R, Ma C, Hu Y, Xia L, Zhao F, Zhang Q, Sun L, Ai D, Cheng X, Qiu L.   +9 more
europepmc   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Revisiting the 2015 MDS diagnostic criteria for Parkinson disease: insights from autopsy-confirmed cases. [PDF]

NPJ Parkinsons Dis
Fox SH, Luca DG, Postuma RB, Bhidayasiri R, Cardoso F, Kovacs GG, Katzenschlager R, Trenkwalder C.   +7 more
europepmc   +1 more source

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

Pseudoachalasia due to Distal Esophageal Squamous Cell Carcinoma in an Elderly Patient: Clinical Insights. [PDF]

Clin Case Rep
Flores CS, Pineda I, Parikh N, Mahmoud HY, Alamin MH.   +4 more
europepmc   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Blue Flag, Red Flag

, 1988
openaire   +1 more source

Implementation and evaluation of the Y-Check comprehensive adolescent health check-up intervention in Zimbabwe: a pre-post mixed-methods study. [PDF]

Nat Med
Doyle AM, Nzvere F, Manyau S, Simms V, Li Lin I, Kandiye FR, Nyamayaro CA, Takawira M, Chingono RMS, Tembo M, Manhibi R, Dauya E, Dziva Chikwari C, Greco G, Bernays S, Baltag V, Maisiri H, Kasu T, Nyamayaro W, Bandason T, Mackworth-Young CRS, Banati P, Weiss HA, Ross DA, Ferrand RA.   +24 more
europepmc   +1 more source

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source