Results 191 to 200 of about 37,257 (258)

Ensemble machine learning for proactive android ransomware detection using network traffic. [PDF]

Sci Rep
Kirubavathi G, Padma Mayuri B, Pranathasree S, Alagappan R, Ajayan A, Ismael WM, Rehman AU.   +6 more
europepmc   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

When diagnostics outpace decisions: mimicry and expansibility in tropical infectious diseases. [PDF]

Trop Med Health
Takahashi H.
europepmc   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Proposed criteria of levels of evidence for co-occurring epilepsy in people with functional/dissociative seizures. [PDF]

Epilepsia
Iyer SN, Duarte Z, Pucci GF, Pirnia T, McFarlane KN, Carns DR, Israel A, Goyette K, Concilus B, Beimer NJ, Pennell PB, O'Neal MA, Strom LA, Kirkpatrick LA, Ta J, Cuello-Oderiz C, Kerr WT.   +16 more
europepmc   +1 more source

Dual‐Key Genetic Circuit Enables Stable and Self‐Regulated Engineered Bacteria for the Treatment of Ulcerative Colitis

Advanced Science, EarlyView.
A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding, Biao Yang, Xinyu Li, Yi Wang, Chunyu Huang, Wenfei Dong, Wei Xie   +6 more
wiley   +1 more source

Seeing elephants and drinking water from a porcelain vase - A case of septin-7 antibody-associated encephalitis presenting as a severe disorganized psychosis. [PDF]

Transl Psychiatry
Gaebler AJ, Arlt FA, Scharf M, Wolking S, Weber Y, Tauber S, Kirchner M, Mertins P, Boy C, Neuner I, Frodl T, Tebartz van Elst L, Prüss H, Novakovic A.   +13 more
europepmc   +1 more source

Management strategies for isolated premature thelarche: a risk-stratified clinical pathway favoring "watchful waiting". [PDF]

Front Endocrinol (Lausanne)
Xu Y, Cui H, Wang X, Liu F.
europepmc   +1 more source

Knowledge and use of thoracic manipulations by manual therapists in Belgium and the Netherlands. [PDF]

J Man Manip Ther
Sokolov A, Beyer B, Van Trijffel E, Scafoglieri A.   +3 more
europepmc   +1 more source

Performance evaluation of the automated haematology analyzer XN-31 for malaria diagnosis in Plasmodium vivax-dominant regions of Thailand. [PDF]

Malar J
Kawaguchi M, Komaki-Yasuda K, Nakatsu M, Kerdsakundee N, Hamana M, Tougan T, Kamei M, Konishi A, Krudsood S, Kano S.   +9 more
europepmc   +1 more source