Results 221 to 230 of about 64,337 (307)

A long-term ecosystem monitoring dataset from the ICP Integrated Monitoring network: biogeochemical data from 1977-2020 across 14 European countries. [PDF]

Sci Data
Weldon J, Aas W, Albiniak B, Augustaitis A, Baužienė I, Capelli C, Clarke N, Cummins T, de Wit HA, Dirnböck T, Djukic I, Eklöf K, Forsius M, Futter M, Grandin U, Gromov S, Šmejkalová AH, Ibañez R, Indriksone I, Jutterström S, Kobler J, Koger H, Kölbl A, Kostrzewski A, Koukhta A, Krám P, Kruszyk R, Lasheras E, Lõhmus K, Majewski M, Makkonen U, Markensten H, Miranda R, Mirtl M, Moldan F, Papitto G, Peterseil J, Pivoras A, Plha T, Pröll G, Rönnback P, Santamaría C, Santamaría JM, Skotak K, Elustondo D, Valerio M, Venier S, Vlaar LE, Ukonmaanaho L, Vuorenmaa J, Wellbrock N.   +50 more
europepmc   +1 more source

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

Detection and Management of Eosinophilia in Asthmatic Adults and Children Receiving Dupilumab Treatment: A Focused Review. [PDF]

J Inflamm Res
Caminati M, Cefaloni F, Tenero L, De Corso E, Micheletto C, Piacentini G.   +5 more
europepmc   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Multidisciplinary Approaches for Diagnosing Underrecognized Transthyretin Amyloidosis in Real-World Practice. [PDF]

Acta Cardiol Sin
Chang HC, Kuo L, Yu TY, Liu YT, Lin KP, Yu WC.   +5 more
europepmc   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source