Results 131 to 140 of about 892,824 (329)

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Perspective: Hollow Core Optical Fibres for Ultraviolet and Visible Wavelengths

Advanced Science, EarlyView.
Hollow core optical fibres bypass material constraints that limit optical fibres at ultraviolet and visible wavelengths. However, their challenging fabrication has limited their development, and significant gains in performance remain possible. In this perspective we outline approaches to enable the next generation of fibres for shorter wavelengths ...
Robbie Mears, Kerrianne Harrington, Jonathan C. Knight, William J. Wadsworth, James M. Stone, Tim A. Birks   +5 more
wiley   +1 more source

Rising Drinking Water Insecurity in the Indian Himalayan Region of Sikkim

Ecology, Economy and Society – The INSEE Journal, 2020
Barun Kumar Thakur, Kanish Debnath, Vaishali Dhingra, Debi Prasad Bal   +3 more
doaj   +1 more source

Hierarchical Strain‐Modified Medium‐Entropy Carbide Ceramics Exhibit Exceptional Ablation Resistance up to 2400°C

Advanced Science, EarlyView.
A novel strategy is developed by doping reduced graphene oxide (rGO) into a (HfZrTi)C medium‐entropy ceramic. This induces a hierarchical strain modification mechanism, synergistically inhibiting crack propagation at the microscale and dissipating stress at the mesoscale.
Junyi Xiao, Pengfei He, Lin Xue, Shujun Hu, Liliang Shao, Chuan Sun, Yunyun Ge, Jiangbo Cheng, Xiubing Liang   +8 more
wiley   +1 more source

Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis

Advanced Science, EarlyView.
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen, Haidong Yu, Dongjiang Lin, Guojun Yang, Yuchen Xie, Yang Zhang, Jifeng Yuan   +6 more
wiley   +1 more source

Enhancing random forest model prediction of gas holdup in internal draft airlift loop contactors with genetic algorithms tuning and interpretability

Scientific Reports
Gas holdup in an Internal Loop Airlift Contactor (ILAC) is one of the primary hydrodynamic features that governs the performance of the contactor. Prediction of gas holdup assumes importance in the design of airlift contactor.
Hardik Prabhu, Charan M. Ravishankar, Abhishek Ganesan, Mayur Pandya, Hrushikesh Bhosale, Renu Dhadwal, Naren Rajan Parlikkad, Patrick Siarry, Jayaraman Krishnamoorthy Valadi   +8 more
doaj   +1 more source

Analysis of combustion efficiency in a pelletizing furnace

REM: International Engineering Journal
The objective of this research is to assess how much the improvement in the combustion reaction efficiency can reduce fuel consumption, maintaining the same thermal energy rate provided by the reaction in a pelletizing furnace.
Rafael Simões Vieira de Moura, Maysa Teixeira Resende, José Antônio da Silva, Julio Cesar Costa Campos   +3 more
doaj   +1 more source

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

Advanced Science, EarlyView.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos, Gustavo Felizardo Santos Sandes, Artur Christian Garcia da Silva, Holli‐Joi Martin, Eugene N. Muratov, Rodolpho de Campos Braga, Bruno Junior Neves   +6 more
wiley   +1 more source

From Design to Prototype: High‐Sensitivity Tri‐Mode Operation Photodetectors Based on 1T‐2H Hybrid MoS2

Advanced Science, EarlyView.
This work demonstrates a phase‐engineered MoS2 photodetector that dynamically switches among photocapacitive (PCC), photovoltaic (PV), and photoconductive (PC) modes. By transforming the traditionally parasitic capacitance into an active signal source, the device achieves self‐powered, high‐sensitivity detection with a fast response of 19.2 ms, and a ...
Xinyu Li, Daxiu Tang, Jiaxin Guo, Xiao Zhang, Sihan Liu, Yaojun Yu, Qianqian Cheng, Chengwei Gao, Xiaoning Guan, Pengfei Lu, Fei Zhuge, Ying Xie, Changgui Lin, Xiang Shen, Haohai Yu, Huaijin Zhang, Jiyang Wang   +16 more
wiley   +1 more source

Nickel‐Catalyzed Twofold Conjunctive Coupling via Philicity‐Alternating Radical Relay

Advanced Science, EarlyView.
Herein, we disclose a nickel‐catalyzed twofold conjunctive coupling that enables a four‐component assembly involving an activated alkene, a 1,3‐enyne, and both alkyl and aryl halides. Multiple C–C bonds are selectively constructed through a philicity‐alternating radical relay and the selective radical capture by the nickel catalyst.
Ji Hwan Jeon, Da Hye Kim, Gun Ha Kim, Gyuhwan Sim, Jan‐Uwe Rohde, Byunghyuck Jung, Sangwon Seo, Sung You Hong   +7 more
wiley   +1 more source