Results 241 to 250 of about 152,357 (314)

Multi response optimization in MQL milling of GTD450 stainless steel using an integrated Taguchi grey relational analysis. [PDF]

Sci Rep
Saberi M, Niknam SA, Hajaliakbari A, Davoodi B, Hashemi R.   +4 more
europepmc   +1 more source

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

A chlorophyll halo over maud rise in the southern ocean. [PDF]

Nat Commun
Ducrocq B, Steiger N, du Plessis M, Sallée JB, Moreau S, Swart S.   +5 more
europepmc   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Analysis of Energy Consumption in the Cutting Zone During Turning Bearing Steel 16MnCr5. [PDF]

Materials (Basel)
Mičietová A, Drbúl M, Čilliková M, Neslušan M.   +3 more
europepmc   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Unusual Presentation of Nephroblastoma in an Adolescent: A Case of Initial Misdiagnosis as a Renal Abscess. [PDF]

Cureus
Jaber M, Alameh W.
europepmc   +1 more source

Atypical presentation of high-grade non-Hodgkin lymphoma in a child: A diagnostic challenge. [PDF]

Radiol Case Rep
Elosiuba E, Elosiuba CH, Vella A, Yarfoh KB.   +3 more
europepmc   +1 more source

Renal Epithelioid Angiomyolipoma: A Case Report. [PDF]

Clin Case Rep
Mehramouz B, Frounchi N, Hadimaleki S, Mehrasa P.   +3 more
europepmc   +1 more source

Evaluation of Serum and Urine GDF-15 Levels in Patients with Ureteral Stones. [PDF]

Diagnostics (Basel)
Akca G, Yigit E, Huner Yigit M, Orman E, Dil E, Uzun H.   +5 more
europepmc   +1 more source