Results 241 to 250 of about 327,861 (339)
Tubeless Percutaneous Nephrolithotomy in the Barts 'Flank-Free' Modified Supine Position with 24-Hour Discharge: A Single-Center Experience. [PDF]
Kiss Z+5 more
europepmc +1 more source
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich+8 more
wiley +1 more source
Metabolic engineering of Parageobacillus thermoglucosidasius for thermophilic production of 1-butanol. [PDF]
Doménech P+5 more
europepmc +1 more source
NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong+18 more
wiley +1 more source
Comparative Analysis of the Dimensional Accuracy and Surface Characteristics of Gears Manufactured Using the 3D Printing (DMLS) Technique from 1.2709 Steel. [PDF]
Sawicki J+6 more
europepmc +1 more source
A high‐strength pH‐responsive hydrogel‐forming microneedle integrates gradient solvent replacement to enhance the mechanical properties of the acrylonitrile‐acrylic acid copolymer network, ensuring robust transdermal penetration and long‐term drug release.
Hui Li+12 more
wiley +1 more source
Transcriptomic characterization of transitioning cell types in the skin of Atlantic salmon. [PDF]
Ruiz Daniels R+15 more
europepmc +1 more source
A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen+16 more
wiley +1 more source