Results 241 to 250 of about 330,691 (353)

Dedifferentiated Liposarcoma of the Kidney: Surgical Management and Diagnostic Insights. [PDF]

Cureus
Khan J, Kashif A, Safdar F, Rashdi PSS, Rehmat SU, Shehzad H.   +5 more
europepmc   +1 more source

The complete sequence of the chicken delta 1 crystallin gene and its 5' flanking region.

, 1985
J M Nickerson, Eric F. Wawrousek, James W. Hawkins, A S Wakil, Graeme Wistow, Gethin Thomas, B. Norman, Joram Piatigorsky   +7 more
openalex   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Changes in the western flank of the North Atlantic subtropical high since 1140 CE: Extremes, drivers, and hydroclimatic patterns. [PDF]

Sci Adv
Bregy JC, Maxwell JT, Robeson SM, Harley GL, Trouet V.   +4 more
europepmc   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

Glucocorticoid-regulated expression from the 5'-flanking region of the rat alpha 1-acid glycoprotein gene. Requirement for ongoing protein synthesis.

, 1987
Elliott Klein, Rosemary Reinke, Philip Feigelson, G M Ringold   +3 more
openalex   +1 more source

Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway

Advanced Science, EarlyView.
A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li, Zhen Shao, Jinsong Li, Naihe Jing, Xianfa Yang   +16 more
wiley   +1 more source

The 10kb Drosophila virus 28S rDNA intervening sequence is flanked by a disect repeat of 14 base pairs of coding sequence

, 1980
Peter M. M. Rae, Bruce D. Kohorn, Robert Wade   +2 more
openalex   +2 more sources

The CXCL10‐CXCR3 Axis Induces Tumor‐Associated Neutrophils to Interfere with CTLs‐Mediated Antitumor Activity in EBV‐Associated Epithelial Cancers

Advanced Science, EarlyView.
Compared with EBV‐negative epithelial cancer cells, EBV‐associated epithelial cancer cells exhibit enhanced secretion of chemokines, including CXCL10 and CCL5, to attract neutrophils. Via the CXCL10‐CXCR3 axis‐mediated positive feedback loop, neutrophils within EBV‐associated epithelial cancer cells are induced to form abundant NETs, which facilitate ...
Dijun Ouyang, Tong Xiang, Yuanyuan Chen, Mengjia Song, Jingjing Zhao, Hao Chen, Si Li, Lifeng Zhang, Chi Xu, Yan Ren, Yong Tao, Qijing Wang, Jia He, Yongqiang Li, Sisi Xie, Yuanyuan Liu, Yan Wang, Xinyi Yang, Jinqi You, Songzuo Xie, Yingzi Li, Desheng Weng, Qiuzhong Pan, Qi Yang, Jianchuan Xia   +24 more
wiley   +1 more source