Results 71 to 80 of about 327,861 (339)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Sonographic Appearance of Abdominal Wall at the Left Flank of Laparotomy Incision Site in Ettawah Grade Does [PDF]
, 2014 The aim of this study was to describe the sonographic appearance of abdominal wall at the left flank of laparotomy incision site in 11 mated Ettawah grade does.
Amrozi, A. (Amrozi) +4 more
core
International Journal of Emergency Medicine, 2009 Bedside ultrasound is becoming a very important tool in emergency medicine. One of the staples of bedside ultrasound is its potential in assisting the clinician with information on local anatomy and organ function. A previously healthy 44-year-old male presented to the emergency department with acute dysuria and left flank pain.
openaire +3 more sources
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
U.S. Law of the Sea Cruise to Map the Southern Flank of the Kingman Reef-Palmyra Atoll section of the Line Islands, Equatorial Pacific Ocean [PDF]
, 2010 U.S. Law of the Sea Cruise to Map the Southern Flank of the Kingman Reef-Palmyra Atoll section of the Line Islands, Equatorial Pacific Ocean CRUISE KM1009 May 17, to June 16, 2010 Pago Pago, American Samoa to Honolulu ...
Calder, Brian R., Gardner, James V.
core +1 more source
Reconstruction of the primary organic productivity of Campano-Maastrichtian shales of Nkporo and Aptian-Albian Awi Formations, Calabar Flank using pigment yield index [PDF]
, 2018 Purpose. To derive the paleo organic productivity exemplified by the pigment yield index in order to resolve the controversy on the petroleum potentials of Nkporo and Awi Formations in Calabar Flank, Southeastern Nigeria. Methods. Twenty outcrop samples
Ibe, K, Ogwuche, C
core +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Chatter, process damping, and chip segmentation in turning: A signal processing approach [PDF]
, 2010 An increasing number of aerospace components are manufactured from titanium and nickel alloys that are difficult to machine due to their thermal and mechanical properties.
Altintas +15 more
core +1 more source
Effect of Cutting Fluids on the Flank Wear of High Speed and Carbide Tipped Cutting Tools
Journal of Applied Sciences and Environmental Management, 2014 The major needs in machining are high material removal rate, good work surface finish and low tool wear. These objectives can be achieved by reducing tool wear using proper cutting fluid during machining.The effect of some cutting fluids namely ...
J Osarenmwinda
doaj +1 more source
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source