Results 341 to 350 of about 318,737 (373)

A Pharmacometric Workflow for Resolving Model Instability in Model Use‐Reuse Settings

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The development of fit‐for‐purpose pharmacokinetic‐pharmacodynamic (PKPD) models based on clinical and pre‐clinical data is a critically important process in model informed drug development. This process is often hampered by modeling stability issues that are often multifactorial in nature and difficult to overcome, leading to protracted model
Stephen B. Duffull, Daniel F. B. Wright, Xiao Zhu, Xin Liu, Ahmed Abulfathi, Hailemichael Hishe   +5 more
wiley   +1 more source

Preferential C-nociceptor stimulation facilitates peripheral axon reflex flare, but not secondary mechanical hyperalgesia. [PDF]

Front Pain Res (Lausanne)
Daneffel L, Rukwied R, Schmelz M, Ruppen W, Schneider T.   +4 more
europepmc   +1 more source

Effects of Galactic Irradiation on Thermal and Electronic Transport in Tungsten

physica status solidi (b), EarlyView.
This atomic‐scale study reveals how low‐to‐mid‐energy space irradiation alters tungsten's thermal and electronic behavior, even at low defect levels. Focusing on vacancy sites in bulk and near grain boundaries, it employs two novel approaches: site‐projected thermal conductivity and the N2$^{2}$ method for the thermal and electronic response analysis ...
Chinonso Ugwumadu, David A. Drabold, Roxanne M. Tutchton   +2 more
wiley   +1 more source

Association of lupus low disease activity state and remission with reduced organ damage and flare in systemic lupus erythematosus patients with high disease activity: a multi-national, longitudinal cohort study. [PDF]

Rheumatology (Oxford)
Kandane-Rathnayake R, Golder V, Louthrenoo W, Chen YH, Cho J, Lateef A, Hamijoyo L, Luo SF, Wu YJ, Navarra SV, Zamora L, Li Z, Sockalingam S, Katsumata Y, Harigai M, Hao Y, Zhang Z, Basnayake BMDB, Chan M, Kikuchi J, Takeuchi T, Bae SC, Oon S, O'Neill S, Goldblatt F, Ng KPL, Law A, Tugnet N, Kumar S, Tee C, Tee M, Ohkubo N, Tanaka Y, Lau CS, Nikpour M, Morand EF, Hoi A.   +36 more
europepmc   +1 more source

Potential roles of antibodies with different classes in IgG4‐related diseases

Rheumatology &Autoimmunity, EarlyView.
This review discussed the common characteristics of different classes of antibodies and their potential corresponding unique mechanisms involved in immunoglobulin G4‐related disease. Abstract Immunoglobulin G4‐related disease (IgG4‐RD), first identified two decades ago, is an immune‐mediated pro‐inflammatory and profibrotic disease entity affecting ...
Ling Li, Shaozhe Cai, Shengyan Lin, Lin Bai, Zhihua Yu, Wei Sun, Lingli Dong   +6 more
wiley   +1 more source

A case of visceral leishmaniasis mimicking connective tissue disease

Rheumatology &Autoimmunity, EarlyView.
Yucui Li, Hongxia Yang, Tingzi Zhao, Ke Xu, Liyun Zhang   +4 more
wiley   +1 more source

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Caught in a Flare

New England Journal of Medicine, 2020
Caught in a Flare This interactive case features a 24-year-old woman with systemic lupus erythematosus who presents with a 1-month history of worsening fatigue, diffuse arthralgias, a rash on her f...
Alisa A. Mueller, Anand Vaidya, Laura L. Tarter, Joshua P. Klein, Ebrahim Barkoudah   +4 more
openaire   +3 more sources

The flare package for high dimensional linear regression and precision matrix estimation in R

Journal of machine learning research, 2020
This paper describes an R package named flare, which implements a family of new high dimensional regression methods (LAD Lasso, SQRT Lasso, ℓ q Lasso, and Dantzig selector) and their extensions to sparse precision matrix estimation (TIGER and CLIME ...
Xingguo Li, T. Zhao, Xiaoming Yuan, Han Liu   +3 more
semanticscholar   +1 more source

Flare periodicity in flare stars? [PDF]

Astrophysics, 1999
Flare periodicity has been found in the flare star Pleiades No. 484. The period of its flare activity is determined from an analysis of the flares’time distribution.
openaire   +1 more source