Results 81 to 90 of about 97,810 (274)

A Mosaic Hotspot PLCD1 Variant, Detectable in Blood‐Derived DNA, Associated With Nevus Trichilemmocysticus

American Journal of Medical Genetics Part A, EarlyView.
Leanne de Kock, Macarena Nougues, Madeline Couse, Wendy Mears, Alison J. Eaton, Kristin D. Kernohan, Care4Rare Canada Consortium, Margarita Larralde, Kym M. Boycott   +8 more
wiley   +1 more source

Efficacy, Safety, Pharmacokinetics, and Immunogenicity of ABBV‐154 in Adults With Glucocorticoid‐Dependent Polymyalgia Rheumatica: A Phase 2, Randomized, Double‐Blind, Placebo‐Controlled Trial

Arthritis &Rheumatology, EarlyView.
Objective An unmet need exists for glucocorticoid‐sparing treatments for patients with polymyalgia rheumatica (PMR). The antibody‐drug conjugate ABBV‐154 comprises adalimumab conjugated to a glucocorticoid receptor modulator. We evaluated ABBV‐154 versus placebo in patients with glucocorticoid‐dependent PMR.
Robert F. Spiera, Valerie Devauchelle‐Pensec, Claire E. Owen, Federico Díaz‐González, Tsutomu Takeuchi, Edit Drescher, Jaclyn Anderson, Dilek Arikan, Ronilda D'Cunha, Julie Parmentier, Denise T. Kruzikas, Weihan Zhao, Yang Yang, Karen Stellpflug, Frank Buttgereit   +14 more
wiley   +1 more source

Early Abnormal Temperature Structure of X-ray Looptop Source of Solar Flares [PDF]

, 2008
This Letter is to investigate the physics of a newly discovered phenomenon -- contracting flare loops in the early phase of solar flares. In classical flare models, which were constructed based on the phenomenon of expansion of flare loops, an energy releasing site is put above flare loops.
arxiv   +1 more source

Sustained Interferon Signature Suppression With Anifrolumab in a Patient With STING‐Associated Vasculopathy with Onset in Infancy Refractory to JAK Inhibitor and Dazukibart Therapy

Arthritis &Rheumatology, EarlyView.
Objective The objective was to report the safety and efficacy of an anti‐IFNAR1 antibody (anifrolumab) in a patient with STING‐associated vasculopathy with onset in infancy (SAVI) who presented with vasculitic ulcers and systemic inflammation refractory to JAK inhibition (JAKi) and to the interferon‐β–neutralizing monoclonal antibody dazukibart ...
Sara Alehashemi, Bjoern Buehring, Adriana A. de Jesus, Sachin Gaurav, Andre Rastegar, Alexi Baumgardner, Kip Friend, Oluwatobi T. Arisa, William D. Figg, Danielle Fink, Douglas B. Kuhns, Ben Colton, Cody J. Peer, Raphaela Goldbach‐Mansky   +13 more
wiley   +1 more source

Using the Maximum X-ray Flux Ratio and X-ray Background to Predict Solar Flare Class [PDF]

, 2015
We present the discovery of a relationship between the maximum ratio of the flare flux (namely, 0.5-4 Ang to the 1-8 Ang flux) and non-flare background (namely, the 1-8 Ang background flux), which clearly separates flares into classes by peak flux level.
arxiv   +1 more source

The Shape of M Dwarf Flares in Kepler Light Curves [PDF]

, 2015
Ultra-precise light curves from Kepler provide the best opportunity to determine rates and statistical properties of stellar flares. From 11 months of data on the active M4 dwarf, GJ 1243, we have built the largest catalog of flares for a single star: over 6100 events.
arxiv   +1 more source

‘Where are the adults?’: Troubling child‐activism and children's political participation

British Educational Research Journal, EarlyView.
Abstract Children's political participation is a well‐established theme in childhood studies. In this article we offer an original account of child activism that takes into account the entangled and emergent aspect of children as activists. We begin with a historical and a conceptual review, noting the importance of mid‐20th century developments such ...
Sharon Hunter, Claire Cassidy
wiley   +1 more source

Topical treatment with the toll‐like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity

Inflammatory Bowel Diseases, EarlyView., 2012
Abstract Background: Patients with chronic active ulcerative colitis (UC) are regarded as treatment failures and represent an area of high unmet medical need, as normally the only remaining option is colectomy. Methods: We treated a total of eight chronic active severe UC outpatients with the immunomodulatory agent DIMS0150 as an add‐on to current ...
Eugen Musch, Tamim Lutfi, Petra von Stein, Arezou Zargari, Charlotte Admyre, Mouhamad Malek, Robert Löfberg, Oliver D. von Stein   +7 more
wiley   +1 more source

Understanding smallholders’ intended deforestation behavior in the Brazilian Cerrado following environmental registry

Environmental Research Letters, 2017
Brazil’s Rural Environmental Registry (CAR) is a potentially promising avenue to slow deforestation on private properties as it facilitates the monitoring of land use.
Laura Vang Rasmussen, Suhyun Jung, Alice Dantas Brites, Cristy Watkins, Arun Agrawal   +4 more
doaj   +1 more source

Gain and Bandwidth Enhancement of 3D-Printed Short Backfire Antennas Using Rim Flaring and Iris Matching

Sensors
In this article, we present new design techniques to improve the gain and impedance bandwidth of short backfire antennas. For the gain enhancement procedure, our approach was to flare the rim of the antenna, which simultaneously led to an increase in the
Yewande Mariam Aragbaiye, Dustin Isleifson   +1 more
doaj   +1 more source