Results 101 to 110 of about 3,427,379 (287)

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Continuous glucose monitoring to improve pregnancy outcomes: a scoping review of the inclusion of persons of colour, minority and indigenous groups in research

Discover Endocrinology and Metabolism
Introduction The burden of type 2 and gestational diabetes in pregnancy is highest amongst those underserved by health systems, including Indigenous peoples, persons of colour, and ethnic minority groups.
Emily Gossen-Perez, Minglan Li, Elizabeth Lewis-Hills, Karaponi Okesene-Gafa, Charlotte Oyston   +4 more
doaj   +1 more source

Comparing glucose monitoring methods: efficiency insights in a simulated hospital setting

Frontiers in Clinical Diabetes and Healthcare
While the advantages of flash glucose monitoring, also known as dynamic interstitial glucose monitoring (DIGM), are established in outpatient diabetes care, evidence of its impact within hospital settings remains limited.
Allan Davasgaium, Allan Davasgaium, Timothy Robbins, Bianca Leca, Bianca Leca, Andreea Epure, Sailesh Sankar, Sailesh Sankar, Harpal Randeva, Harpal Randeva   +9 more
doaj   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Application of flash glucose monitoring system in postoperative blood glucose management of kidney transplant recipients

Huli yanjiu, 2021
ObjectiveTo investigate the application effect of flash glucose monitoring （FGM） in blood glucose management of kidney transplant recipients （KTRs） with post⁃transplantation diabetes mellitus （PTDM）.MethodsA total of 36 PTDM cases of KTRs were ...
LU Xingxing, LIU Jing
doaj  

Flash Glucose Monitoring: The Future Is Here [PDF]

Diabetes Technology & Therapeutics, 2017
Satish K, Garg, Halis Kaan, Akturk
openaire   +2 more sources

DataSheet_1_Efficacy of Flash Glucose Monitoring in Type 1 and Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.zip

, 2022
ObjectiveFlash glucose monitoring (FlashGM) is a sensor-based technology that displays glucose readings and trends to people with diabetes. In this meta-analysis, we assessed the effect of FlashGM on glycaemic outcomes including HbA1c, time in range ...
Digsu N. Koye (8881108), Bonnie Liang (12116082), Elif I. Ekinci (3623126), Mariam Hachem (12116085), Neda Zafari (668066), Sabine Braat (4480366)   +5 more
core   +1 more source

Immune Biomarkers of Islet Transplant Rejection Revealed by Synthetic Immunological Niche

Advanced Science, EarlyView.
A subcutaneous synthetic immunological niche (IN) enables serial, minimally invasive monitoring of immune responses after islet transplantation. Flow cytometry and transcriptomic profiling of the IN reveal immune‐cell programs associated with graft acceptance and distinct types of rejection.
Jyotirmoy Roy, Abdalmonam Jadou Nejma, Mohammad Tarique, Amod Talekar, Shengli Wu, Brianna Ha, Yifei Jiang, Esma S. Yolcu, Lonnie D. Shea   +8 more
wiley   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Patient‐Personalized Membrane‐Coated Magnetic Nanovectors: Probing the Biomimetic Interface for Targeted Tumor Theranostics

Advanced NanoBiomed Research, EarlyView.
This study presents a label‐free spectroscopic platform to evaluate membrane protein conformation on patient‐derived glioblastoma cell membrane‐coated magnetic nanovectors. This work demonstrates that preserving membrane protein integrity during nanoparticle fabrication enhances homotypic tumor targeting and reduces hard protein corona formation ...
Daniele De Pasquale, Michela Patrucco, Melike Belenli Gümüş, Alessandra Flori, Luca Menichetti, Stefania Moscato, Valentina Bonanni, Alessandra Gianoncelli, Milan Žižić, Pietro Fiaschi, Monica Truffelli, Andrea Bianconi, Melis Emanet, Gianmarco Ferri, Chiara Maria Mazzanti, Carlotta Pucci, Gianni Ciofani   +16 more
wiley   +1 more source