Results 231 to 240 of about 3,427,379 (287)

Harnessing the Horse for Human Osteoarthritis: microRNA‐181a‐5p Antisense Oligonucleotides in Clinically Normal Equine Fetlock Joints Are Safe and Well Tolerated

Journal of Orthopaedic Research, Volume 44, Issue 11, November 2026.
ABSTRACT Horses serve as a translational model for human osteoarthritis (OA) due to their comparable joint size, cartilage thickness, and incidence of naturally occurring disease. Overexpression of microRNA‐181a‐5p has been implicated in cartilage degradation in OA, and its inhibition using locked nucleic acid antisense oligonucleotides (LNA‐miR‐181a ...
T. Connor McCorkell, Narman Mortagy, Rodrigo Munevar Luque, Thomas G. Koch, Janet Beeler‐Marfisi, Y. Raja Rampersaud, Jonathan Lamarre, Mohit Kapoor, Judith B. Koenig   +8 more
wiley   +1 more source

Beyond monofunctionality: structural perspectives on phenol oxidase side activity in a catalase

Acta Crystallographica Section D, Volume 82, Issue 11, Page 1224-1239, November 2026.
Structural and biochemical characterization of the extracellular fungal catalase ClCPO uncovers an unexpected phenol oxidase promiscuity. Crystal structures, substrate docking and electron‐transfer pathway analysis identify ligand‐binding regions and support a working mechanistic model for catalase‐associated phenol oxidase activity.Catalases are ...
Christina Ferousi, Christos Kosinas, Odyssefs Ioannis Pantelakis, Efstratios Nikolaivits, Evangelos Topakas, Maria Dimarogona   +5 more
wiley   +1 more source

Metabolomic Signatures of Longevity in Bivalves Reveal Reorganization of TCA Cycle and Amino Acid Metabolism

Aging Cell, Volume 25, Issue 11, November 2026.
Targeted metabolomics of gill and mantle tissues from five marine bivalve species spanning lifespans from approximately 30 to over 500 years revealed longevity‐associated metabolic signatures. Longer‐lived species exhibited reduced free amino acid pools, lactate, pyruvate‐related ratios, fumarate and malate, alongside increased succinate‐to‐fumarate ...
Pauline Bertrand, Clément J. L. Chevret, Enrique Rodríguez, Hélène Lemieux, Pierre U. Blier   +4 more
wiley   +1 more source

Diffusely impaired myocardial perfusion in patients with suspected coronary artery disease: Clinical utility of relative perfusion

Clinical Physiology and Functional Imaging, Volume 46, Issue 6, November 2026.
Abstract Background In patients with suspected coronary artery disease (CAD), diffusely impaired hyperaemic myocardial blood flow (MBF) may indicate a multivessel epicardial CAD but also impaired coronary microcirculation. We assessed whether relative hyperaemic MBF—that is, the ratio of the lowest to the highest regional hyperaemic MBF—predicts ...
Niklas Vartiainen, Antti‐Pekka E. Rissanen, Suvi Hartikainen, Svantte Halttunen, Aleksi J. Leikas, Elina Kariniemi, Eero Strengell, Paavo‐Ilari Kuikka, Juha E. K. Hartikainen, Tomi P. Laitinen   +9 more
wiley   +1 more source

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis

Immunology, Volume 179, Issue 3, Page 418-433, November 2026.
Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao, Gillian A. Carleton, Sam Preshaw, Sarah MacPherson, Madison Shiyuk, Joseph Monaghan, Jun Han, Oro Uchenunu, Robert Rottapel, Ralph J. DeBerardinis, Kelly M. Stewart, Bo‐Hyun Kim, Juan Ausió, David R. Goodlett, Helena Pětrošová, Kyle D. Duncan, Julian J. Lum   +16 more
wiley   +1 more source

Can flash glucose monitoring improve glucose management for Aboriginal and Torres Strait Islander peoples with type 2 diabetes? A protocol for a randomised controlled trial. [PDF]

Trials
Hachem M, Hearn T, Kelly R, Eer A, Moore B, Sommerville C, Atkinson-Briggs S, Twigg S, Freund M, O'Neal D, Story D, Brown A, McLean A, Sinha A, Furler J, O'Brien R, Tran-Duy A, Clarke P, Braat S, Koye DN, Eades S, Burchill L, Ekinci E.   +22 more
europepmc   +1 more source

Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta

Plant, Cell &Environment, Volume 49, Issue 11, Page 8306-8321, November 2026.
ABSTRACT Characterization of previously reported Arabidopsis mutants with increased aluminum (Al) resistance (alr) resulting from greater release of Al‐chelating malate identified three unique amino acid substitutions that each impacts PHOSPHOENOLPYRUVATE CARBOXYLASE 1, a key anaplerotic carbon fixation enzyme.
Jinrui Sheng, Kevin Frausto, Sarah Haesaerts, Taylor J. Meyer, Maruša Prolič‐Kalinšek, Seán E. O'Leary, Remy Loris, Paul B. Larsen   +7 more
wiley   +1 more source

Loss of Acid Ceramidase in Myeloid Cells Protects From Chronic Colitis in IL10‐Deficient Mice

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Acid ceramidase converts ceramide to sphingosine which can then be converted to sphingosine‐1‐phosphate, a bioactive lipid involved in inflammation. Loss of acid ceramidase in myeloid cells protects from chronic colitis by reducing pro‐inflammatory markers, increasing ceramides, and reducing effector immune cells in the colon.
Keila S. Espinoza, Brandon K. Dahl, Ella M. Ryan, Mary R. Gordon, Chelsea L. Doll, Marilyn T. Marron, Cameron A. Beard, Pujarini D. Dey, David G. Besselsen, Richard J. Simpson, Justin M. Snider, Justin E. Wilson, Pawel R. Kiela, Ashley J. Snider   +13 more
wiley   +1 more source

Correction: Can flash glucose monitoring improve glucose management for Aboriginal and Torres Strait Islander peoples with type 2 diabetes? A protocol for a randomised controlled trial. [PDF]

Trials
Hachem M, Hearn T, Kelly R, Eer A, Moore B, Sommerville C, Atkinson-Briggs S, Twigg S, Freund M, O'Neal D, Story D, Brown A, McLean A, Sinha A, Furler J, O'Brien R, Tran-Duy A, Clarke P, Braat S, Koye DN, Eades S, Burchill L, Ekinci E.   +22 more
europepmc   +1 more source

Tuning the Triazolotriazine Scaffold Toward Selective A3 Adenosine Receptor Antagonists: From Molecular Recognition to Neuroprotection

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Structure‐based optimization of the triazolo‐triazine scaffold afforded highly potent and selective adenosine A3 receptor antagonists. Replacement of the classical 2‐furyl group with phenyl‐based substituents markedly improved A3 receptor affinity and selectivity.
Veronika Kost, Filippo Prencipe, Federica Panozzi, Veronica Salmaso, Sonja Kachler, Karl‐Norbert Klotz, Elisabetta Coppi, Simone Adorinni, Stefano Moro, Anna Maria Pugliese, Stephanie Federico, Giampiero Spalluto, Tatiana Da Ros   +12 more
wiley   +1 more source