Results 61 to 70 of about 2,749,079 (229)

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Visual evoked potentials show strong positive association with intracranial pressure in patients with cryptococcal meningitis

Arquivos de Neuro-Psiquiatria, 2015
Objective : To verify the relationship between intracranial pressure and flash visual evoked potentials (F-VEP) in patients with cryptococcal meningitis.
Marcelo Adriano da Cunha Silva Vieira, Maria do Amparo Salmito Cavalcanti, Dorcas Lamounier Costa, Kelsen Dantas Eulálio, Otoni Cardoso do Vale, Chrystiany Placido de Brito Vieira, Carlos Henrique Nery Costa   +6 more
doaj   +1 more source

Longitudinal Awake Mouse Brain Imaging Using Functional Ultrasound and Functional Ultrasound Localization Microscopy

Advanced Science, EarlyView.
Awake longitudinal multimodal ultrasound imaging integrates functional ultrasound (fUS), ultrasound localization microscopy (ULM), and functional ULM (fULM) to characterize cerebrovascular function, microvascular architecture, and flow dynamics within the same animals over time.
Zhe Huang, Yike Wang, Matthew R. Lowerison, Yue Xu, Murong Yi, Bing‐Ze Lin, YiRang Shin, Nathiya Vaithiyalingam Chandra Sekaran, Daniel A. Llano, Pengfei Song   +9 more
wiley   +1 more source

Visual Evoked Potentials (VEP) in Graves’ Disease Patients in Siriraj Hospital

Siriraj Medical Journal, 2017
Objective: To evaluate the visual evoked potentials (VEP) in Graves’ disease patients in order to reveal the possible presen- tation of subclinical optic neuropathy.
Atiporn Thuangtong, Chonlada Wangvarunyoo, Tada Kunavisarut, Nitinun Phithakphaosakul   +3 more
doaj  

Subclinical Abnormalities of Visual Evoked Potentials and Blink Reflex in Patients with Fibromyalgia

Neurological Sciences and Neurophysiology
Aims: Previous studies on event-related evoked potentials have suggested potential abnormalities in patients with fibromyalgia. This study aimed to investigate whether patients with fibromyalgia exhibited alterations in visual evoked potentials (VEPs ...
Sidika Buyukvural Sen, Halil Can Alaydin, Halit Fidanci   +2 more
doaj   +1 more source

Electrophysiolocal findings in Mohr-Tranebjærg syndrome

Revista Brasileira de Oftalmologia, 2015
Mohr-Tranebjærg syndrome (MTS) is an X-liked recessive rare syndrome also known as deafness-dystonia syndrome. The severity of the symptoms may vary, but they progress usually to severe deafness and dystonia and sometimes they are accompanied by cortical
Regina Halfeld Furtado de Mendonça, Eliana Lucia Ferreira, Stefania Abbruzzese   +2 more
doaj   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Flash Electroretinography and Pattern Visual Evoked Potential Changes in Ocular Hypertension Patients

Journal of Ophthalmology, 2013
Purpose. To evaluate the changes of flash electroretinography (fERG) and pattern visual evoked potentials (pVEP) in ocular hypertension (OHT) patients. Methods.
Ercüment Çavdar, Abdullah Ozkaya, Burcu Alper   +2 more
doaj   +1 more source

Time-resolved influences of functional DAT1 and COMT variants on visual perception and post-processing [PDF]

, 2012
BACKGROUND: Dopamine plays an important role in orienting and the regulation of selective attention to relevant stimulus characteristics. Thus, we examined the influences of functional variants related to dopamine inactivation in the dopamine transporter
Laucht, Manfred (Prof. Dr.), Rellum Thomas, Thomas Rellum, Resch, Franz, Stephan Bender, Brandeis, Daniel, Banaschewski, Tobias, Laucht Manfred, Bender, Stephan, Rietschel, Marcella, Jennen-Steinmetz, Christine, Freitag, Christine M., Treutlein, Jens, Jens Treutlein, Rellum, Thomas, Daniel Brandeis, Brandeis Daniel, Tobias Banaschewski, Jennen-Steinmetz Christine, Christine Freitag, Bender Stephan, Banaschewski Tobias, Manfred Laucht, Freitag, Christine, Franz Resch, Rietschel Marcella, Marcella Rietschel, Resch Franz, Christine Jennen-Steinmetz, Laucht, Manfred, Treutlein Jens, Freitag Christine   +31 more
core   +2 more sources