Advanced Science, EarlyView.Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang +12 more
wiley +1 more source
Advanced Science, EarlyView.AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie +14 more
wiley +1 more source
Clinical Thermography of the Diabetic Foot Using a Low-Cost Thermal Camera: Processing and Instrumental Framework. [PDF]
Sensors (Basel)Chingan-Martino V +5 more
europepmc +1 more source
Advanced Science, EarlyView.Non‐invasively quantitative Raman imaging with stacking‐induced charge transfer‐enhanced Raman scattering (SICTERS) enables accurate measurement of concentrations and pharmacokinetic modeling of lymphatic transport of micelles in mice. This platform allows dynamic analysis of nanoparticle transport and underpins the design of effective lymph node ...
Yunlu Li +6 more
wiley +1 more source
Acrokeratosis verruciformis of Hopf: Genetic, clinicopathologic and therapeutic features (Review). [PDF]
Med Int (Lond)Kostopoulos-Kanitakis KA, Kanitakis J.
europepmc +1 more source
Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair
Advanced Science, EarlyView.Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou +14 more
wiley +1 more source
A Case Report of a Novel Myelin Protein Zero (<i>MPZ</i>) Pathogenic Variant in Charcot-Marie-Tooth Disease Combined With Type 2 Diabetes. [PDF]
Case Rep GenetXia L +6 more
europepmc +1 more source
A Scalable Double‐Sided Wet Etching Strategy for Large‐Area Mushroom‐Shaped Bionic Adhesives
Advanced Science, EarlyView.This work presents a scalable manufacturing strategy for high‐performance, large‐area, mushroom‐shaped bio‐inspired adhesives. Using a double‐sided wet etching process, the complex 3D metal molds are fabricated rapidly and controllably. The resulting adhesive structures exhibit strong, stable adhesion under various conditions, including atmosphere and ...
Keju Ji +8 more
wiley +1 more source
Lateral Wedge Insoles With and Without Contoured Arch Support for People With Knee Osteoarthritis and Foot Pain: A Pilot, Feasibility Randomized Controlled Trial. [PDF]
J Foot Ankle ResHunt MA +5 more
europepmc +1 more source
On the Role of Preprocessing and Memristor Dynamics in Reservoir Computing for Image Classification
Advanced Electronic Materials, EarlyView.ABSTRACT Reservoir computing (RC) is an emerging recurrent neural network architecture that has attracted growing attention for its low training cost and modest hardware requirements. Memristor‐based circuits are particularly promising for RC, as their intrinsic dynamics can reduce network size and parameter overhead in tasks such as time‐series ...
Rishona Daniels +4 more
wiley +1 more source