Results 41 to 50 of about 781,099 (282)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Effectiveness of jumping rope combined with short foot exercise on the medial longitudinal arch in a patient with flat foot: A case report [PDF]
Journal of Sports and Rehabilitation SciencesA flat foot is a deformity that leads to the collapse of the medial longitudinal arch. Flat foot may be congenital or acquired, which can be treated with various exercises; short foot exercise is where the head of the first metatarsal is pulled towards ...
Chaithanya P +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
PENGARUH SHORT FOOT EXERCISE TERHADAP MEDIAL LONGITUDINAL ARCH PADA PENDERITA FLAT FOOT: NARRATIVE REVIEW [PDF]
, 2021 Latar Belakang: Flat foot atau pes planus adalah kondisi dimana lengkungan arkus telapak kaki mengalami peurunan yang dapat terjadi pada anak-anak hingga orang dewasa, flat foot terjadi sekitar 20-30% populasi secara global.
Tri Laksono, S.ST.FT., M.S PT +2 more
core +1 more source
Research on Dynamic Parameters of a Passive Walking Robot with Flat Feet
Jixie chuandong, 2022 In order to study the influence of dynamic parameters on the gait of biped robots, a passive walking robot with flat feet is taken as the research object, the dynamic equation using Lagrange method and conservation of angular momentum is established and ...
Gao Jiachang, Gao Jianshe, Tao Zheng
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source