Results 121 to 130 of about 147,718 (411)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Installation package for air flat plate collector [PDF]

The Solar 2 dimensions are four feet by eight feet by two and one half inches. The collector weighs 130 pounds and has an effective solar collection area of over 29.5 square feet. This area represents 95 percent of the total surface of the collector. The

core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Energetic and exergetic study of a flat plate collector based solar water heater - investigation of the absorber size

EAI Endorsed Transactions on Energy Web
Small sized absorber in a flat plate solar collector is beneficial in terms of cost and minimum heat losses. However, its detailed thermal performance compared to standard size collector is still not fully understood.
Kumar Aditya Chandra, Bishal Podder, Supreme Das, Agnimitra Biswas   +3 more
doaj   +1 more source

Discussion: “The Performance of Flat-Plate Solar-Heat Collectors” (Hottel, H. C., and Woertz, B. B., 1942, Trans. ASME, 64, pp. 91–103) [PDF]

, 1942
F. A. Brooks
openalex   +1 more source

OPTIMIZATION OF AN INTEGRAL FLAT PLATE COLLECTOR-STORAGE SYSTEM FOR DOMESTIC SOLAR WATER HEATING IN ADANA

, 2018
In this paper, the optimum orientation and sizing of a thermosyphon flat plate collector−storage solar water heating system were determined using the typical meteorological year data for Adana, Turkey.
İ. Yılmaz
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Experimental and Theoretical Study for Performance Enhancement of Air Solar Collectors by Using Different Absorbers

Al-Khawarizmi Engineering Journal, 2017
An experimental and theoretical study has been done to investigate the thermal performance of different types of air solar collectors, In this work air solar collector with a dimensions of (120 cm x90 cm x12 cm) , was tested under climate condition of ...
Ahmed A. Mohammad Saleh, Taher Abbas Rashid   +1 more
doaj  

Design, Modelling and Experimental Investigation of an Economic Domestic STHW System Using T*Sol® Simulation in Botswana

MATEC Web of Conferences, 2018
The study describes a research and development directed at examining research and design a SHWS, and test a flat-plate solar collector capable of collection efficiency in excess of 50 percent at an inlet fluid temperature 22ºC.
Seretse O.M., Agarwal A., Letsatsi M.T., Moloko O.M., Batlhalefi M.S.   +4 more
doaj   +1 more source