An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Remote Sensing Inversion of Full-Profile Topography Data for Coastal Wetlands Using Synergistic Multi-Platform Sensors from Space, Air, and Ground. [PDF]
Zhang J, Wang J, Dai Y, Miao Y, Li H.
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Audience segmentation and messaging approach to gain public support and involvement in coastal social-ecological system management. [PDF]
Uehara T, Hidaka T, Tachibana S.
europepmc +1 more source
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Moving to a "flat with referee" in older age: an embodied and social transition. [PDF]
Gfeller F, Zittoun T.
europepmc +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Taxonomic, genomic, and ecological insights into a novel Flavobacteriaceae strain from coastal tidal flats. [PDF]
Wang H +7 more
europepmc +1 more source
The accelerating loss and shifting dynamics of US tidal wetlands. [PDF]
Yang X +6 more
europepmc +1 more source
Prevention Is the Best Strategy to Solve Coastal Eutrophication. [PDF]
Hayashi K +5 more
europepmc +1 more source

