Results 141 to 150 of about 68,853 (304)

Posttranslational modifications of heterologous proteins expressed in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
Summary The success of Nicotiana benthamiana as a workhorse for heterologous protein production is closely linked to its accessibility and tolerance to genetic manipulation, allowing efficient engineering of posttranslational protein modifications (PTMs) that are critical for the function and stability of heterologous proteins.
Kathrin Göritzer, Somanath Kallolimath, Richard Strasser   +2 more
wiley   +1 more source

A 212-nt long RNA structure in the Tobacco necrosis virus-D RNA genome is resistant to Xrn degradation [PDF]

, 2019
Plus-strand RNA viruses can accumulate viral RNA degradation products during infections. Some of these decay intermediates are generated by the cytosolic 5′-to-3′ exoribonuclease Xrn1 (mammals and yeast) or Xrn4 (plants) and are formed when the enzyme ...
Chaminda, Gunawardene D., Newburn, Laura R., White, K. Andrew   +2 more
core   +1 more source

Zika virus surveillance post‐epidemic in blood donors from São Paulo, Brazil 2016–2020

Transfusion Medicine, EarlyView.
Abstract Introduction Zika virus (ZIKV) is primarily transmitted through the bite of the Aedes aegypti mosquito, though transmission via blood transfusion has also been documented. During the 2015 ZIKV epidemic in Brazil, severe complications were observed in pregnant women, leading to fetal microcephaly. This study evaluated the persistence of ZIKV in
Suzete Cleusa Ferreira, José Eduardo Levi, Anna Shoko Nishiya, Cesar de Almeida‐Neto, Jerenice Esdras Ferreira, Juliana Derriga, Nanci A. Salles, Silvia Petrossi Gallo Polato, Katia C. Dantas, Edmir Boturão‐Neto, Martha Mathias Rocha, Vanderson Rocha, Alfredo Mendrone‐Jr   +12 more
wiley   +1 more source

Historical Perspectives on Flavivirus Research [PDF]

Viruses, 2017
The flaviviruses are small single-stranded RNA viruses that are typically transmitted by mosquito or tick vectors. These “arboviruses” are found around the world and account for a significant number of cases of human disease. The flaviviruses cause diseases ranging from mild or sub-clinical infections to lethal hemorrhagic fever or encephalitis.
openaire   +3 more sources

Wolbachia and arbovirus inhibition in mosquitoes [PDF]

, 2013
Wolbachia is a maternally inherited intracellular bacteria that can manipulate the reproduction of their insect hosts, and cytoplasmic incompatibility allows them to spread through mosquito populations.
Sinkins, Steven P.
core   +1 more source

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Nature Communications, 2019
The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood.
X. Zhuang, A. Magrì, M. Hill, Alvina G. Lai, Abhinav Kumar, S. B. Rambhatla, Claire L. Donald, A. Lopez-Clavijo, S. Rudge, Katherine E. Pinnick, Wai Hoong Chang, P. Wing, Ryan Brown, Ximing Qin, P. Simmonds, T. Baumert, D. Ray, A. Loudon, P. Balfe, M. Wakelam, S. Butterworth, A. Kohl, C. Jopling, N. Zitzmann, J. McKeating   +24 more
semanticscholar   +1 more source

Role of RNA-binding proteins during the late stages of Flavivirus replication cycle

Virology Journal, 2020
The genus Flavivirus encompasses several worldwide-distributed arthropod-borne viruses including, dengue virus, Japanese encephalitis virus, West Nile virus, yellow fever virus, Zika virus, and tick-borne encephalitis virus.
Mayra Diosa-Toro, K. R. Prasanth, Shelton S Bradrick, Shelton S Bradrick, Mariano A. Garcia Blanco, Mariano A. Garcia Blanco   +5 more
semanticscholar   +1 more source

The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer

International Journal of Cancer, Volume 157, Issue 12, Page 2434-2446, 15 December 2025.
Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley   +1 more source

Culex quinquefasciatus mosquitoes do not support replication of Zika virus [PDF]

, 2017
The rapid spread of Zika virus (ZIKV) in the Americas raised many questions about the role of Culex quinquefasciatus mosquitoes in transmission, in addition to the key role played by the vector Aedes aegypti.
Failloux, Anna-Bella, Guimarães Rocha Aguiarr, Eric Roberto, Kohl, Alain, Lourenço-de-Oliveira, Ricardo, Marques, João T., Nten, Célestine Atyame, Sreenu, Vattipally B., Varjak, Margus   +7 more
core   +2 more sources

Notification of the first isolation of Cacipacore virus in a human in the State of Rondônia, Brazil

Revista da Sociedade Brasileira de Medicina Tropical, 2011
Flavivirus is a genus of arthropod-transmitted viruses of the family Flaviviridae, and in Brazil, up to eleven different Flavivirus have been isolated. We collected blood from farmers in the municipality of Theobroma, which is located 320km from the City
Weber Cheli Batista, Glauciane da Silva Bifano Tavares, Deusilene Souza Vieira, Eduardo Rezende Honda, Soraya Santos Pereira, Mauro Shugiro Tada   +5 more
doaj   +1 more source