Results 291 to 300 of about 68,853 (304)

Dynamics of Flavivirus Infection in Mosquitoes

2003
Abstract Mosquito-borne flaviviruses are emerging as the cause of some of the most serious and widespread arthropod-borne viral diseases in the world. Flavivirus outbreaks are influenced by intrinsic (e.g., viral strain, vector competence, host susceptibility) and extrinsic (e.g., temperature, rainfall, human land use) factors that affect mosquito ...
Laura D. Kramer, Gregory D. Ebel
openaire   +3 more sources

A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus

Science Translational Medicine, 2019
Insect-specific Binjari virus facilitates the production of chimeric virus particles of flavivirus pathogens for diagnostics and vaccines. Fighting flavi with flavi Insect-transmitted flaviviruses can cause hemorrhagic fever in humans and contribute to ...
J. Hobson-Peters, J. Harrison, D. Watterson, J. Hazlewood, Laura J. Vet, N. Newton, D. Warrilow, Agathe M. G. Colmant, Carmel T Taylor, Bixing Huang, Thisun B. H. Piyasena, W. Chow, Y. X. Setoh, B. Tang, E. Nakayama, Kexin Yan, Alberto A. Amarilla, Sarah Wheatley, P. Moore, Mitchell Finger, N. Kurucz, Naphak Modhiran, P. Young, A. Khromykh, H. Bielefeldt-Ohmann, A. Suhrbier, R. Hall   +26 more
semanticscholar   +1 more source

The role of anti‐flavivirus humoral immune response in protection and pathogenesis

Reviews in Medical Virology, 2020
Flavivirus infections are a public health threat in the world that requires the development of safe and effective vaccines. Therefore, the understanding of the anti‐flavivirus humoral immune response is fundamental to future studies on flavivirus ...
A. M. Hurtado-Monzón, C. D. Cordero-Rivera, Carlos Noe Farfán-Morales, J. F. Osuna-Ramos, L. A. De Jesús-González, J. Reyes-Ruíz, R. D. del Ángel   +6 more
semanticscholar   +1 more source

A Small Molecule Inhibitor of ATPase activity of HSP70 As Broad-Spectrum Inhibitor Against Flavivirus Infections.

ACS Infectious Diseases, 2020
Flaviviruses including Zika virus, Dengue virus, Japanese Encephalitis virus and Yellow Fever virus cause heavy burdens to public health around the world. No specific antiviral drug was available in clinic against these flavivirus infections.
Jingjing Yang, Yongfen Xu, Yunzheng Yan, Wei Li, Lei Zhao, Qingsong Dai, Yuexiang Li, Song Li, Jin Zhong, Ruiyuan Cao, Wu Zhong   +10 more
semanticscholar   +1 more source

Flavivirus Replication Strategy

1987
Publisher Summary The family Flaviviridae comprises 65 species, which globally represent the most widespread and medically important of the arthropod-borne viruses. Knowledge of flavivirus replication strategy has accumulated slowly—current information indicates that the strategy is apparently simple, involving the genome as the single capped ...
openaire   +3 more sources

Zika virus: An emerging flavivirus

Journal of Microbiology, 2017
Zika virus (ZIKV) is a previously little-known flavivirus closely related to Japanese encephalitis, West Nile, dengue, and yellow fever viruses, all of which are primarily transmitted by blood-sucking mosquitoes. Since its discovery in Uganda in 1947, ZIKV has continued to expand its geographic range, from equatorial Africa and Asia to the Pacific ...
Sang-Im Yun, Young-Min Lee
openaire   +2 more sources

Flavivirus and its Threat

2021
A number of studies found that the virus can activate the endothelial cells and affect the structure and function of the blood?brain barrier, promoting immune cell migration to benefit the virus nervous system target cells infected by flaviviruses.
openaire   +1 more source

Unraveling a Flavivirus Enigma

Science, 2014
The structure of a flavirirus nonstructural protein provides mechanistic understanding for many of its functions. [Also see Report by Akey et al. ]
openaire   +2 more sources

Flavivirus genome organization, expression, and replication.

Annual Review of Microbiology, 1990
T. Chambers, C. Hahn, R. Galler, C. Rice
semanticscholar   +1 more source

Establishment and Application of Flavivirus Replicons

2018
Dengue virus (DENV) and Zika virus (ZIKV) are enveloped, positive-strand RNA viruses belonging to the genus Flavivirus in the family Flaviviridae. The genome of ~11 kb length encodes one long open reading frame flanked by a 5' and a 3' untranslated region (UTR). The 5' end is capped and the 3' end lacks a poly(A) tail. The encoded single polyprotein is
openaire   +3 more sources