Results 181 to 190 of about 10,263 (261)

Interactions between membrane-bound streptococcal alpha-enolase and human plasminogen captured through cryogenic-electron microscopy. [PDF]

Front Mol Biosci
Tjia-Fleck S, Readnour BM, Liang Z, Ayinuola YA, Castellino FJ.   +4 more
europepmc   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Demonstrating soft X-ray tomography in the lab for correlative cryogenic biological imaging using X-rays and light microscopy. [PDF]

Sci Rep
O'Connor S, Rogers D, Kobylynska M, Geraets JA, Thaysen K, Egebjerg JM, Brink MC, Herbsleb L, Salakova M, Fuchs L, Alves F, Feldmann C, Ekman A, Sheridan P, Fyans W, McEnroe T, O'Reilly F, Fahy K, Fleck RA, Wüstner D, Simpson JC, Walter A, Kapishnikov S.   +22 more
europepmc   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Publisher Correction: An integrated transcriptomic cell atlas of human neural organoids. [PDF]

Nature
He Z, Dony L, Fleck JS, Szałata A, Li KX, Slišković I, Lin HC, Santel M, Atamian A, Quadrato G, Sun J, Pașca SP, Human Cell Atlas Organoid Biological Network, Camp JG, Theis FJ, Treutlein B.   +15 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Translation and cross-cultural validation of the Flourishing and Secure Flourishing Indexes into Brazilian Portuguese. [PDF]

Braz J Psychiatry
Gonçalves JPB, Costa MA, Rocha NSD, Manfro G, Alvarenga WA, Moreira-Almeida A, Paz BM, Fleck MPA, Lucchetti G, Vallada H.   +9 more
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Is first-pass effect a meaningful metric to evaluate thrombectomy technologies? [PDF]

Interv Neuroradiol
Agrawal A, Agrawal AS, Howell JL, Barringer-Hoonhout SB, Fleck JD, Mackey JS, DeNardo AJ, Gibson DP, Amuluru K, Saleem Y, Kulwin CG, Payner TD, Shah KJ, Mocco J, Sahlein DH.   +14 more
europepmc   +1 more source