Results 161 to 170 of about 1,692,376 (297)

The climate opportunities and risks of contrail avoidance. [PDF]

Nat Commun
Smith JR, Grobler C, Hodgson PJ, Mukhopadhaya J, Shapiro ML, Mirolo M, Stettler MEJ, Eastham SD, Barrett SRH.   +8 more
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Admiral Sperry at the official reception during the visit of the American Fleet in Australia, Sydney, 1908 [picture].

, 1908
Title devised by cataloguer based on inscription.; Part of the collection: American Fleet in Australia, 1908.; Inscriptions: "12,898 The American Fleet in Australia. Rear-Admiral Sperry at the official reception, Lower Domain, Sydney.

core  

The future fate of Somali upwelling productivity and the implications for fisheries under climate change. [PDF]

Sci Rep
Jacobs ZL, Jebri F, Bruggeman J, Baker C, James F, Srokosz M, Yool A, Loveridge A, Popova E.   +8 more
europepmc   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

United States sailors leaving St. Patrick's Cathedral, during the visit of the American Fleet in Australia, Melbourne, 1908 [picture].

, 1908
Title devised by cataloguer based on inscription.; Part of the collection: American Fleet in Australia, 1908.; Inscriptions: "12,871 The American Fleet in Australia. St. Patrick's Cathedral Melbourne. Sailors leaving after the service.

core  

Cradle-to-gate life cycle assessment of sisal/PLA biocomposite: Uncovering the dominance of transport and burden-shifting trade-offs in sustainable material design. [PDF]

PLoS One
Kahigi NS, Machunda R, Mkunda JJ, Mwema MF.   +3 more
europepmc   +1 more source

Ablation‐Immune Thermal Armor Via Microstructural‐Compatibility Design for Extreme Thermal Conditions

Advanced Science, EarlyView.
This study unveils a microstructural‐compatibility design strategy that integrates reactive melt infiltration with plasma spraying to fabricate carbon fiber‐reinforced ZrC‐SiC composites. The deliberate incorporation of SiC into the ZrC coating releases heat accumulation, suppresses detrimental lamellar ZrO2 formation, and reduces residual stress. This
Hongkang Ou, Lingxiang Guo, Bing Liu, Ziyi Yi, Yuyu Zhang, Jia Sun, Qiangang Fu   +6 more
wiley   +1 more source

Maritime sector pathways toward net-zero emissions within global energy scenarios. [PDF]

Sci Rep
Kramel D, Krey V, Fricko O, Maczek F, Muri H, Strømman AH.   +5 more
europepmc   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source