Results 21 to 30 of about 188,341 (195)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Estudio Comparativo con prótesis total de rodilla de alta flexión. [Comparative ­study ­with ­high-flex ­total ­knee­ arthroplasty.]

Revista de la Asociación Argentina de Ortopedia y Traumatología, 2014
In­tro­duc­ción: El objetivo de este trabajo comparativo fue analizar los resultados funcionales y el rango de movimiento de rodilla entre dos grupos de pacientes con artroplastia total de rodilla: uno utilizando prótesis de alta flexión y el otro con un
Matías Costa Paz
doaj   +1 more source

Association between passive stiffness of hamstring and eccentric knee flexion angle-torque relationship

Journal of Physical Fitness and Sports Medicine, 2021
Larger hip flexion range of motion with knee extension (hip flexion ROM) and passive stiffness of the hamstring is associated with greater production of isometric and concentric knee flexion torque at longer muscle lengths.
Satoru Nishida, Shun Kunugi, Kiyoshi Maehara, Shumpei Miyakawa   +3 more
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Partículas modales de la flexión verbal

Anuario del Seminario de Filología Vasca "Julio de Urquijo", 1988
The author recalls the existence in Basque of three types of particle that may precede the conjugated verb, always following this sequence: a) ba/ez, focusing particles for affirmation and negation; b) al/bide/ei/omen/ote, modal particles; c) ba-/bait ...
José A. Mujika
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Flexión esviada: estado actual del tema

Informes de la Construccion, 1970
Se presentan brevemente las diversas posibilidades existentes para el dimensionamiento práctico de secciones de hormigón armado solicitadas en flexocompresión esviada, en el marco del cálculo en rotura.
F. Morán, A. Verde
doaj   +1 more source

The posterior tibial slope does not influence the flexion angle in posterior-stabilized mobile-bearing total knee arthroplasty

Arthroplasty, 2021
Background It remains uncertain whether an increase in the tibial slope leads to better flexion in posterior-stabilized (PS) total knee prostheses. Purpose To compare the intra-operative flexion angle between standard and an additional 10° posterior ...
Susumu Takemura, Tessyu Ikawa, Yohei Ohyama, Mitsunari Kim, Kunio Takaoka, Yukihide Minoda, Yoshinori Kadoya   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source