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Engineered Prime Editors with PAM flexibility [PDF]
Molecular Therapy, 2020 AbstractAlthough prime editors are a powerful tool for genome editing, which can generate various types of mutations such as nucleotide substitutions, insertions, and deletions in the genome without double-strand breaks or donor DNA, the conventional prime editors are still limited to its target scopes because of the PAM preference of the spCas9 ...
Jiyeon Kweon +7 more
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Structural Damage Assessment Using Multiple-Stage Dynamic Flexibility Analysis
Aerospace, 2022 Vibration-based damage assessment technology is a hot topic in aerospace engineering, civil engineering, and mechanical engineering. In this paper, a damage assessment approach using multiple-stage dynamic flexibility analysis is proposed for structural ...
Yun Sun , Qiuwei Yang, Xi Peng
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iScience, 2022 Summary: In nature, many organisms (e.g., chameleons) protect themselves by changing their colors in response to environmental changes. Inspired by these organisms, we present a multi-responsive, flexible, and structurally colored hydrogel film with a ...
Xiaoxiang Wen +6 more
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Quantification of the Flexibility of Residential Prosumers
Energies, 2021 Balancing in a distributed generation network is an increasingly difficult task because of the increasing number of residential prosumers on the power network.
István G. Balázs +2 more
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TYPOLOGY OF MANUFACTURING FLEXIBILITY IN THE ENGINEERING INDUSTRY: A REVIEW [PDF]
Acta Tecnología, 2016 Classification of manufacturing flexibility represents a risk for the company as face this challenge. Reactions to these changes, based on late responses market leading executives to flexible manufacturing.
Lucia Knapčíková, Jozef Husár
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Frontiers in Microbiology, 2023 Introductionβ-Mannanases can hydrolyze mannans, which are widely available in nature. However, the optimum temperature of most β-mannanases is too low to be directly utilized in industry.MethodsTo further improve the thermostability of Anman (mannanase ...
Shundong Tan +7 more
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Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering. [PDF]
PLoS ONE, 2016 Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) each give rise to a vast array of complex bioactive molecules with further complexity added by the existence of natural PKS-NRPS fusions.
Maria Lund Nielsen +6 more
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iScience, 2022 Summary: Demand response (DR) is rapidly gaining attention as a solution to enhance the grid reliability with deep renewable energy penetration. Although studies have demonstrated the benefits of DR in mitigating price volatility, there is limited work ...
Kiyeob Lee +6 more
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EDITORIAL: New Horizon for Industrial Engineering and Management [PDF]
International Journal of Industrial Engineering and Management, 2021 Another volume is behind us, with 24 papers discussing exciting topics in industrial engineering and management. The Fourth Industrial Revolution has brought disruptive changes in academic research and industrial practices in manufacturing.
Ugljesa Marjanovic
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Increasing design flexibility by manually adapting the solution space for crashworthiness
Journal of Mathematics in Industry, 2023 The solution space methodology, as presented in 2013, was meant to guide developers at the very beginning of the development process of a new mechanically crashworthy car.
Paolo Ascia +2 more
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