Results 51 to 60 of about 1,173,607 (300)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Flexible automation in the U.S. engineering industries [PDF]
International Journal of Industrial Organization, 1991 Abstract The changes in manufacturing systems and industrial structure brought about by the development of new, computer-based flexible technologies has been a subject of growing debate during the last decade. There is a lack of solid empirical support for almost all hypotheses developed in this debate since data on the relative use of various ...
openaire +2 more sources
Charge Transfer Induced Polarity Switching in Carbon Nanotube Transistors
, 2005 We probed the charge transfer interaction between the amine-containing molecules: hydrazine, polyaniline and aminobutyl phosphonic acid, and carbon nanotube field effect transistors (CNTFETs).
Afzali, Ali +3 more
core +1 more source
Reusable Knowledge-based Components for Building Software Applications: A Knowledge Modelling Approach [PDF]
, 1999 In computer science, different types of reusable components for building software applications were proposed as a direct consequence of the emergence of new software programming paradigms. The success of these components for building applications depends
Cuena, José +2 more
core +5 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Chain flexibility of medicinal lipids determines their selective partitioning into lipid droplets
Nature Communications, 2022 Lipid droplet (LD) is a highly dynamic organelle capable of regulating lipid metabolism, storage and transportation. Here, by combining molecular dynamics simulations and microbial LD engineering, the authors demonstrate that the structural flexibility ...
So-Hee Son +5 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Analytic Methods for Solving Higher Order Ordinary Differential Equations
Mathematics, 2019 In this work, an analytic approach for solving higher order ordinary differential equations (ODEs) is developed. The techniques offer analytic flexibility in many research areas such as physics, engineering, and applied sciences and are effective for ...
Maria P. Beccar-Varela +3 more
doaj +1 more source
The Flexible Pocketome Engine for Structural Chemogenomics [PDF]
, 2009 Biological metabolites, substrates, cofactors, chemical probes, and drugs bind to flexible pockets in multiple biological macromolecules to exert their biological effect. The rapid growth of the structural databases and sequence data, including SNPs and disease-related genome modifications, complemented by the new cutting-edge 3D docking, scoring, and ...
Ruben, Abagyan, Irina, Kufareva
openaire +2 more sources