Results 71 to 80 of about 4,007,356 (365)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Flexibility features in patent writing [PDF]
Ibérica, 2012 International patents are increasingly demanded in academic circles as a sign of excellence and compete with situated genres such as projects, grants, PhD supervisions, books and journal articles, especially in hard science environments.
Carmen Sancho-Guinda
doaj
Type Inference in Flexible Model-Driven Engineering [PDF]
, 2015 In Model-Driven Engineering (MDE), models conform to metamodels. In flexible modelling, engineers construct example models with free-form drawing tools; these examples may later need to conform to a metamodel. Flexible modelling can lead to errors: drawn elements that should represent the same domain concept could instantiate different types; other ...
Zolotas, Athanasios +4 more
openaire +2 more sources
Multidisciplinary Engineering: Flexibility And Abet Accreditation [PDF]
2009 Annual Conference & Exposition Proceedings, 2020 Comment: 19 ...
Phillip Wankat, Kamyar Haghighi
openaire +2 more sources
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Effect of non-repetitive linker on in vitro and in vivo properties of an anti-VEGF scFv
Scientific Reports, 2022 Single chain antibody fragments (scFvs) are favored in diagnostic and therapeutic fields thanks to their small size and the availability of various engineering approaches.
Merve Arslan +5 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
iScience, 2019 Summary: With rapid declines in solar photovoltaic (PV) and energy storage costs, futures with PV penetrations approaching or exceeding 50% of total annual US generation are becoming conceivable.
Bethany Frew +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source