Results 91 to 100 of about 196,547 (296)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

High-Level Object Oriented Genetic Programming in Logistic Warehouse Optimization [PDF]

open access: yes, 2014
Disertační práce je zaměřena na optimalizaci průběhu pracovních operací v logistických skladech a distribučních centrech. Hlavním cílem je optimalizovat procesy plánování, rozvrhování a odbavování.
Karásek, Jan
core  

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Intercompartmental communication in senescence

open access: yesFEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz   +3 more
wiley   +1 more source

Dynamic scheduling of hybrid flow shop problem with uncertain process time and flexible maintenance using NeuroEvolution of Augmenting Topologies

open access: yesIET Collaborative Intelligent Manufacturing
A hybrid flow shop is pivotal in modern manufacturing systems, where various emergencies and disturbances occur within the smart manufacturing context. Efficiently solving the dynamic hybrid flow shop scheduling problem (HFSP), characterised by dynamic ...
Yarong Chen   +4 more
doaj   +1 more source

An Improved Genetic-Simulated Annealing Algorithm Based on a Hormone Modulation Mechanism for a Flexible Flow-Shop Scheduling Problem

open access: yesAdvances in Mechanical Engineering, 2013
A flexible flow-shop scheduling (FFS) with nonidentical parallel machines for minimizing the maximum completion time or makespan is a well-known combinational problem.
Min Dai   +3 more
doaj   +1 more source

Dynamic scheduling in a multi-product manufacturing system [PDF]

open access: yes, 2005
To remain competitive in global marketplace, manufacturing companies need to improve their operational practices. One of the methods to increase competitiveness in manufacturing is by implementing proper scheduling system. This is important to enable job
Hassan, Adnan   +2 more
core  

Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki   +8 more
wiley   +1 more source

Applying TOC Heuristics to Job Scheduling in a Hybrid Flexible Flow Shop

open access: yesDyna, 2014
Este artículo presenta una aplicación de la heurística para la mezcla de productos de la Teoría de Restricciones, a la planificación de tareas en un Flow Shop híbrido flexible.
Jaime Antero Arango-Marín   +2 more
doaj  

A Novel Metaheuristics To Solve Mixed Shop Scheduling Problems

open access: yes, 2013
This paper represents the metaheuristics proposed for solving a class of Shop Scheduling problem. The Bacterial Foraging Optimization algorithm is featured with Ant Colony Optimization algorithm and proposed as a natural inspired computing approach to ...
Ravibabu, V.
core   +1 more source

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