Results 61 to 70 of about 4,432,432 (296)

Lot streaming and batch scheduling: splitting and grouping jobs to improve production efficiency

open access: yes, 2001
This thesis deals with issues arising in manufacturing, in particular related to production efficiency. Lot streaming refers to the process of splitting jobs to move production through several stages as quickly as possible, whereas batch scheduling ...
Possani, Edgar
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Improved discrete cuckoo‐search algorithm for mixed no‐idle permutation flow shop scheduling with consideration of energy consumption

open access: yesIET Collaborative Intelligent Manufacturing, 2021
The increasing number and types of industrial tasks require factories to be more flexible in production. An improved discrete cuckoo search algorithm (CSA) is proposed and used to optimise the mixed no‐idle permutation flow shop scheduling problem ...
Lingchong Zhong   +3 more
doaj   +1 more source

Uma abordagem difusa para o problema de flow-shop scheduling [PDF]

open access: yes, 1999
Tese (Doutorado) - Universidade Federal de Santa Catarina, Centro ...
Cury, Ricardo Martins
core  

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Dynamic scheduling of hybrid flow shop problem with uncertain process time and flexible maintenance using NeuroEvolution of Augmenting Topologies

open access: yesIET Collaborative Intelligent Manufacturing
A hybrid flow shop is pivotal in modern manufacturing systems, where various emergencies and disturbances occur within the smart manufacturing context. Efficiently solving the dynamic hybrid flow shop scheduling problem (HFSP), characterised by dynamic ...
Yarong Chen   +4 more
doaj   +1 more source

A novel Tiki-Taka algorithm to optimize hybrid flow shop scheduling with energy consumption

open access: yesEngineering and Applied Science Research, 2022
Hybrid flow shop scheduling (HFS) has been thoroughly studied due to its significant impact on productivity. Besides the impact on productivity, the abovementioned problem has attracted researchers from different background because of its difficulty in ...
Mohd Fadzil Faisae Ab Rashid   +1 more
doaj  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

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