Results 51 to 60 of about 4,188 (302)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

An Adaptive Real-Time Scheduling Method for Flexible Job Shop Scheduling Problem With Combined Processing Constraint

open access: yesIEEE Access, 2019
Flexible job shop scheduling problem with combined processing constraint is a common scheduling problem in assembly manufacturing industry. However, traditional methods for classic flexible job shop scheduling problem (FJSP) cannot be directly applied ...
Haihua Zhu   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A hybrid genetic approach to solve real make-to-order job shop scheduling problems [PDF]

open access: yes, 1997
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro TecnologicoProcedimentos de busca local (ex. busca tabu) e algoritmos genéticos têm apresentado excelentes resultados em problemas clássicos de programação da produção em ambientes job ...
Candido, Marco Antonio Barbosa
core  

Flexible job shop scheduling using genetic algorithm and heuristic rules

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2016
Job shop scheduling with the availability of more than one machine to perform an operation, also known as the flexible job shop scheduling problem, is computationally NP-hard.
Parinya KAWEEGITBUNDIT, Toru EGUCHI
doaj   +1 more source

Flexible job‐shop scheduling problem by genetic algorithm

open access: yesElectrical Engineering in Japan, 2009
AbstractThe Flexible Job‐shop Scheduling Problem is an expansion of the traditional Job‐shop Scheduling Problem in which an operation can be processed by one or more machines. The purpose of this problem is to look for the smallest makespan. For that purpose, it is necessary to decide the optimal assignment of machines to operations and the order of ...
Ida, Kenichi, Oka, Kensaku
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Multi-Objective Flexible Job Shop Scheduling Using Genetic Algorithms

open access: yes, 2022
Flexible Job Shop Scheduling is an important problem in the fields of combinatorial optimization and production management. This research addresses multi-objective flexible job shop scheduling problem with the objective of simultaneous minimization of ...
Elbadawi, Isam A-Q   +5 more
core   +1 more source

An Energy-Efficient Scheduling Approach for Flexible Job Shop Problem in an Internet of Manufacturing Things Environment

open access: yesIEEE Access, 2019
This paper addresses the energy-efficient scheduling and real-time control of flexible job shop that requires rescheduling affected operations and updating the scheduling. For energy-efficient scheduling shop floor efficiently, we propose a metaheuristic
Songling Tian   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

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