Results 71 to 80 of about 1,810,420 (307)

Dynamic stabilization versus fusion for treatment of degenerative spine conditions. [PDF]

open access: yes, 2011
Study design Comparative effectiveness review.Study rationale Spinal fusion is believed to accelerate the degeneration of the vertebral segment above or below the fusion site, a condition called adjacent segment disease (ASD).
Chou, Dean   +3 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

The sustainability of communicative packaging concepts in the food supply chain. A case study: part 1. Life cycle assessment [PDF]

open access: yes, 2011
Purpose In recent years, a new perspective for food packaging has emerged as a result of several issues like quality, safety, competitive prices or providing of useful information to consumers.
Cordero, P.   +6 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A feasibility evaluation of oral pressure therapy for the treatment of obstructive sleep apnea

open access: yesTherapeutic Advances in Respiratory Disease, 2013
Objective: This feasibility study examined the initial-use safety and potential utility of a novel noninvasive oral pressure therapy (OPT) system designed to reduce airway obstruction during sleep.
Mehran Farid-Moayer   +2 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Policies for an Ageing Workforce Work-life balance, working conditions and equal opportunities 2019 [PDF]

open access: yes, 2019
At a time of rapid population ageing, a key means of sustaining current welfare states is to extend the length of working lives. In 2050, the share of people over the age of 75 years will be the same as the share over 65 years today.
Anderson, Robert   +18 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Development of low-carbon technologies in China's integrated hydrogen supply and power system

open access: yesAdvances in Climate Change Research
Hydrogen and electricity are crucial and interdependent energy carriers in China's pursuit of carbon neutrality, suggesting the necessity of utilizing cost-effective low-carbon technologies that facilitate their integrated development.
Dai-Wei Li   +4 more
doaj   +1 more source

Analysis of optimum wire rope configuration for equal unidirectional torsional stiffness for flexible steering shaft

open access: yesMATEC Web of Conferences, 2016
The design and modeling of Low Stiffness Resilience Shaft (LSRS) for the Semi-Active Steering (SAS) system using wire ropes is discussed in this paper, along with the static structural torsion test simulation of the wire ropes in order to determine the ...
Hussain Najaf   +2 more
doaj   +1 more source

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