Results 271 to 280 of about 555,243 (314)

Structural diversity and flexibility of diabodies

Methods, 2019
Diabodies are bispecific antibody fragments that have two antigen binding Fv domains. They are unique among hundreds of different formats of bispecific antibodies because they are small and rigid enough to be crystallized. Diabodies are generated by connecting variable regions of heavy and light chains by a peptide linker.
Kwon, Na-Young, KIM, YOUNGJIN, LEE, JIE OH   +2 more
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Resource Flexibility and Capital Structure

Management Science, 2012
This paper examines how the optimal investment in the capacity of flexible and nonflexible resources is affected by financial leverage and, conversely, how a firm's resource flexibility affects its optimal capital structure. We consider a two-product firm that invests in the optimal capacity of product-flexible and product-dedicated resources in the ...
Jiri Chod, Jianer Zhou
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ADAPTIVE CONTROL OF A FLEXIBLE STRUCTURE

IFAC Proceedings Volumes, 1987
Abstract The design of a high-performance adaptive controller is discussed for an experimental lightly-damped flexible structure. The plant, the Stanford Four-Disk System, sustains large step changes in parameters as payload mass is added. New methods that make use of limited a priori knowledge of the plant are shown not only to greatly improve the ...
M.D. Sidman, G.F. Franklin
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The structural basis of DNA flexibility

Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences, 2004
Although the average physico-chemical properties of a long DNA molecule may approximate to those of a thin isotropic homogeneous rod, DNA behaves more locally as an anisotropic heterogeneous rod. This bending anisotropy is sequence dependent and to a first approximation reflects both the geometry and stability of individual base steps.
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The protein secondary structure flexibility

2008
Modeling protein flexibility is a long standing challenge in computational biology with a special impact to protein docking. Relating problems are protein structures alignment and identification of flexible and rigid protein regions, as well as a general definition of a region degree of flexibility.
Šikić, Krešimir, Tomić, Sanja, Jeren, Branko   +2 more
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The structured flexibility of Orton-Gillingham

Annals of Dyslexia, 1991
This paper discusses a philosophic basis for Orton-Gillingham teaching and attempts to demonstrate how certain of the features of such multisensory teaching act to remediate language problems exhibited by many dyslexic students. The common basis of the array of programs coming from both Orton and Gillingham is addressed.
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Flexible Querying of Structured Documents

2001
In this paper a flexible query language for expressing soft selection conditions on structured documents is presented and formalized within fuzzy set theory. Documents are represented as entities structured into logical sections in which the index terms play a distinct role. Users can indicate the preferred sections of documents, i.e., those which they
Gloria Bordogna, Gabriella Pasi
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Flexibility of Network Structures

Journal of Solid State Chemistry, 1996
Abstract Understanding the flexibility of network structures is important for comprehending how such structures react to changing pressure and temperature as well as intercalation reactions. Some network structures are highly flexible, whereas others are rather rigid. Simple modeling approaches can offer some understanding of this behavior.
N. Khosrovani, A.W. Sleight
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Alignment of flexible protein structures.

Proceedings. International Conference on Intelligent Systems for Molecular Biology, 2001
We present two algorithms which align flexible protein structures. Both apply efficient structural pattern detection and graph theoretic techniques. The FlexProt algorithm simultaneously detects the hinge regions and aligns the rigid subparts of the molecules.
Maxim Shatsky, Zipora Y. Fligelman, Ruth Nussinov, Haim J. Wolfson   +3 more
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Structural Flexibility in Hydrated Proteins

The Journal of Physical Chemistry B, 2008
The flexibility of protein structures is important in allowing the variety of motions, covering a wide range of magnitudes and frequencies, essential to biological activity. Protein flexibility is also implicated in denaturation, allowing proteins to take up nonactive conformations that have free energies close to that of the native state.
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