Results 101 to 110 of about 2,402,993 (303)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Investigation of the machinability of (001) single-crystal β-Ga2O3 via tribological methodology

Nanotechnology and Precision Engineering
Gallium oxide (Ga2O3) is a promising material for next-generation power devices due to its ultrawide bandgap and extremely high critical electric field strength; however, the strong anisotropy and cleavage tendency of Ga2O3 pose significant challenges ...
Shuo Li, Peng Gao, Guosong Zeng
doaj   +1 more source

Flexible Spectral Precoding for OFDM Systems

Proceedings, 2019
Spectral precoding is a popular approach to reduce out-of-band radiation (OBR) in multicarrier systems in order to avoid adjacent channel interference. However, it introduces distortion in the data, appropriate decoding is required at the receiver side ...
Khawar Hussain, Roberto López-Valcarce
doaj   +1 more source

Motion control and vibration suppression of flexible lumped systems via sensorless LQR control [PDF]

, 2011
This work attempts to achieve motion control along with vibration suppression of flexible systems by developing a sensorless closed loop LQR controller. Vibration suppression is used as a performance index that has to be minimized so that motion control ...
Celebi, Besir, Cevik, Gulnihal, Mehmet, Berkem, Sabanovic, Asif, Shoukry Mohammed Khalil, Islam, Çelebi, Beşir, Çevik, Gülnihal, Şabanoviç, Asif   +7 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Surface Planarization‐Epitaxial Growth Enables Uniform 2D/3D Heterojunctions for Efficient and Stable Perovskite Solar Modules

Advanced Science
Two‐dimensional/three‐dimensional (2D/3D) halide perovskite heterojunctions are widely used to improve the efficiency and stability of perovskite solar cells.
Dongxu Lin, Jun Fang, Sibo Li, Zhenye Zhan, Huan Li, Xin Wang, Guanshui Xie, Daozeng Wang, Nuanshan Huang, Haichen Peng, Weiguang Xie, Luis K. Ono, Yabing Qi, Longbin Qiu   +13 more
doaj   +1 more source

Interface regulation of micro-sized sintered Ag-10Al composite based on in-situ surface modification and enhanced microstructure stability in power electronic packaging

Materials & Design
The increasing demand for high-power SiC semiconductors necessitate the development of a die attachment material that combines high-temperature resistance, reliability, and cost-effectiveness.
Fupeng Huo, Chuantong Chen, Zheng Zhang, Ye Wang, Aiji Suetake, Kazutaka Takeshita, Yoshiji Yamaguchi, Yashima Momose, Katsuaki Suganuma   +8 more
doaj   +1 more source

Expressing Privacy Preferences in terms of Invasiveness [PDF]

, 2004
Dynamic context aware systems need highly flexible privacy protection mechanisms. We describe an extension to an existing RBAC-based mechanism that utilises a dynamic measure of invasiveness to determine whether contextual information should be ...
Osbakk, Patrik, Ryan, Nick S.
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Flexible systems and their effectiveness in designing interior spaces(Private university buildings as a model)

الاكاديمي
The idea and philosophy of flexible systems and their effectiveness in the field of interior design came as one of the important influential points to confront future developments and to lay the foundations for achieving all functional and aesthetic ...
Abdel-Zahra Odeh Hassan , Rajaa Saadi Lafta   +1 more
doaj   +1 more source