Results 151 to 160 of about 60,701 (249)

A Drive-Vibration Integrated Piezoelectric Actuator for Flexible Electrode Implantation. [PDF]

Micromachines (Basel)
Li X, Wu D, Lin X, Jiang T, Ma J, Li Y, Hu Y, Wang Y, Zhong H, Yang X, Li J, Wen J.   +11 more
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Locomotion Control Strategy Design and Simulation of Parallel-Legged Insect-Scale Micro Crawling Robot. [PDF]

Biomimetics (Basel)
Zhu Q, Jiang T, Luo Z, Zhu Y, Huang G.
europepmc   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

Design and Optimization of High-Amplification-Ratio Micromanipulator Based on Compliant Mechanism. [PDF]

Micromachines (Basel)
Zhao F, Huang W, Liao J, Chen X, Zhai F, Chen X.   +5 more
europepmc   +1 more source

Translational Barriers and AI‐Driven Challenges of Microfluidics‐Enabled Wearables and Implantable Systems in Personalized Medicine

Advanced Science, EarlyView.
An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang, Ching Yin Fong, Xin Huang, Bee Luan Khoo   +3 more
wiley   +1 more source

Design and Performance Analysis of Orthogonal Compliant Vector Force Measuring System

Jixie chuandong
Aiming at the design challenges of multi-branch orthogonal compliant test stand, a finite element method with beam connection units is proposed, and finite element models of force branches and test stand are established using this method.
Zhang Leile, Li Dong, Zheng Guoliang, Ma Qianli   +3 more
doaj  

Adaptive Inverse Control Using the Krasnosel'skii-Pokrovskii Model for Hysteresis Compensation in Piezoelectric Flexure Micro-Positioning Stage. [PDF]

Micromachines (Basel)
Chen Y, Lou H, Wang J, Liu S.
europepmc   +1 more source

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Long-Tailed Multi-Label Diagnosis of Compound Faults in Wind Turbine Gearboxes via Multi-Channel Imaging of FBG Vibration Signals. [PDF]

Sensors (Basel)
Peng Y, Duan X, Tian H, Liu H, Liu T, Zhang W, Chen K, Shu Z, Chen W.   +8 more
europepmc   +1 more source