Results 151 to 160 of about 17,122 (260)

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Anomalous contrast as an adaptive violation of the Talbot-Plateau law. [PDF]

Doc Ophthalmol
Greene E, Morrison J.
europepmc   +1 more source

Predicting the Reactivity of Acyclic Silylenes and Germylenes in Hydrogen Activation Using Machine Learning

Advanced Science, EarlyView.
Statistical models for the prediction of the energy profile of H2 activation by silylenes and germylenes were developed. A simple model based on increments of the elements in α‐position enabled robust energy prediction, extrapolation to new structures, and transferability to new tetrylenes and substrates.
Michelle Kleinhaus, Henning Remm, Prasenjit Palui, Alexander Linke, Viktoria H. Gessner   +4 more
wiley   +1 more source

Effects of short-term moderate versus high intraocular pressure elevation on flicker-induced changes in full-field electroretinogram. [PDF]

Doc Ophthalmol
Rai M, Yang X, Choi KY, Tan S, Chan HH.
europepmc   +1 more source

A Thirty‐Year Gap: Reviving All‐Nitride Glasses as Processable, High‐Performance Materials

Advanced Science, EarlyView.
Oxygen‐free all‐nitride glasses are revisited in light of new avenues of synthesis, raw material availability, and applications. A semi‐empirical analysis predicts mechanical performance achieving the level of engineering ceramics while maintaining visual transparency, and significant potential regarding optical properties into the infrared spectral ...
Alexis Duval, Tor Grande, Lothar Wondraczek   +2 more
wiley   +1 more source

Thalamocortical network dynamics can explain visual impulse responses and perceptual echoes. [PDF]

iScience
Schwenk JCB, Hagan MA, Cloherty SL, Zavitz E, Morris AP, Price NSC, Rosa MGP, Alamia A, Bremmer F.   +8 more
europepmc   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

Retinal Neurophysiological Parameters in Young Patients With Type 1 Diabetes. [PDF]

Invest Ophthalmol Vis Sci
Torm MEW, Johannesen J, Gardner TW, Hajari JN, Klefter ON, Larsen M.   +5 more
europepmc   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Retinal microvascular alterations consistent with endothelial dysregulation in paediatric post-COVID-19 syndrome: A prospective matched-cohort study. [PDF]

Sci Rep
Lamprecht PS, Streese L, Hauser C, Hanssen H, Lorenz M, Klee S, Proquitté H, Vilser D.   +7 more
europepmc   +1 more source