Results 251 to 260 of about 139,586 (335)

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Brain Gamma-Stimulation: Mechanisms and Optimization of Impact. [PDF]

Biology (Basel)
Lushnikov KV, Serov DA, Astashev ME, Kozlov VA, Melerzanov A, Vedunova MV.   +5 more
europepmc   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Development of a Memory Clinic at an Aboriginal Community-Controlled Health Service: Profile of the First Patients. [PDF]

Australas J Ageing
Hyde Z, Flicker L, Douglas R, Rind S, Rind N, LoGiudice D, Smith K.   +6 more
europepmc   +1 more source

Synergistic Effects of Solid Electrolyte Mild Sintering and Lithium Surface Passivation for Enhanced Lithium Metal Cycling in All‐Solid‐State Batteries

Advanced Science, EarlyView.
This study proposes a synergistic strategy combining mild sintering of solid electrolyte pellets with lithium metal surface passivation, effectively suppressing dendrite growth, and enhancing interfacial stability. This approach doubles the critical current density of symmetric cells (1.1 to 2.2 mA cm−2) and extends full cells cycle life at 1 mA cm−2 ...
Jinsong Zhang, Robin N. Wullich, Thomas J. Schmidt, Mario El Kazzi   +3 more
wiley   +1 more source

Minimizing Pupil Size Dependence in Flicker ERG Using Stiles-Crawford Compensation. [PDF]

Transl Vis Sci Technol
Kato K, Davis CQ, Zeinali N, Sugawara A, Matsubara H, Sugimoto M, Kashima Y, Mizumoto K, Kudo H, Nagasaka E, McCulloch DL, Kondo M.   +11 more
europepmc   +1 more source

Efficacy of Subconjunctivally Applied Everolimus- and Sirolimus-Pretreated MSCs in Preventing Diabetic Retinopathy. [PDF]

Transl Vis Sci Technol
Jung JS, Jo HY, Hwang J, Kim D, Kwon M, Yong J, Yoon H, Lee HJ, Park KM.   +8 more
europepmc   +1 more source

Optimization of Dynamic SSVEP Paradigms for Practical Application: Low-Fatigue Design with Coordinated Trajectory and Speed Modulation and Gaming Validation. [PDF]

Sensors (Basel)
Huang Y, Cao L, Chen Y, Wang T.
europepmc   +1 more source

Fundamentals of 1/f noise reduction technique based on complementary cascode switching applied to a 52 microwatts 5.2pJ/bit 100Kb/s 120 GHz receiver. [PDF]

Sci Rep
Sanduleanu M.
europepmc   +1 more source

Re-evaluating the choice of gamma stimulation frequency for the potential treatment of Alzheimer's disease: Novel invisible spectral flicker evokes gamma responses at various frequencies. [PDF]

PLoS One
Henney MA, Hansen BL, Hansen LS, Grønberg MG, Thorning-Schmidt MW, Hansen HE, Nguyen M, Petersen PM, Clemmensen LKH, Carstensen M, Madsen KH.   +10 more
europepmc   +1 more source