Results 1 to 10 of about 540,987 (358)
Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance
Molecular Oncology, EarlyView., 2023 Glioblastoma is one of the most lethal human cancers with no effective treatment nowadays. Here, we review the increasing amount of evidence supporting the connection between cell signaling deregulation and metabolic reprogramming as a key event in glioblastoma resistance to cancer therapy.
Laura Zarzuela +2 more
wiley +1 more source
Advanced Biology, Volume 6, Issue 12, December 2022., 2022 Fabrication of a lithography‐less Cayley‐tree pattern to generate a blood‐brain barrier‐on‐a‐chip. The shape of the microchannels in the Cayley‐tree pattern is semi‐elliptical with smooth variation in the height of the microchannels from the parent branch to daughter branches.
Ami Mehta +9 more
wiley +1 more source
Performance analysis of control allocation using data‐driven integral quadratic constraints
Advanced Control for Applications, Volume 4, Issue 4, December 2022., 2022 Abstract A new method is presented for evaluating the performance of a nonlinear control allocation system within a linear control loop. To that end, a worst‐case gain analysis problem is formulated that can be readily solved by means of well‐established methods from robustness analysis using integral quadratic constraints (IQCs).
Manuel Pusch +2 more
wiley +1 more source
Tailored Torsion and Bending‐Resistant Avian‐Inspired Structures
Advanced Engineering Materials, Volume 24, Issue 12, December 2022., 2022 Avian bones are prominent candidates for addressing the torsional and bending issue. They present a unique intertwining of simple components: helicoidal ridges and criss‐crossing struts, bearing flexural and twisting actions of winds. Here, it is set how to harmonically move from the natural to the engineering level to formalize and analyze the ...
Federica Buccino +4 more
wiley +1 more source
Book review of “Here, there, everywhere—A memoir” by Peter Almond
, 2022 Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022.
Bruce J. Gerbi
wiley +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Suppression of amber stop codons impairs pathogenicity in Salmonella
FEBS Letters, EarlyView.Stop‐codon suppression by natural and engineered tRNAs creates new protein variants. Amber suppression at UAG codons occurs in nature and is frequently used to incorporate noncanonical amino acids into proteins. We show that amber suppression in Salmonella attenuates expression of SPI‐1 virulence genes by decreasing the activity of the master regulator
Zhihui Lyu +3 more
wiley +1 more source
Inhibition of autophagy as a novel treatment for neurofibromatosis type 1 tumors
Molecular Oncology, EarlyView.We used synthetic lethal screens to find new approaches to treat neurofibromatosis type 1 (NF1) tumors. Inhibition of autophagy was identified as a robust method to selectively kill NF1‐deficient cells with minimal effects on healthy cells. Following assessment of a range of autophagy inhibitors, we determined that chloroquine has strong potential for ...
Megan Stevens +9 more
wiley +1 more source
Protein crystallization and structure determination at room temperature in the CrystalChip
FEBS Open Bio, EarlyView.This protocol describes the implementation of a simple and user‐friendly microfluidic device called CrystalChip that allows the production of crystals by the counter‐diffusion method and their in situ analysis by serial crystallography. As an illustration, it is applied to determine the 3D structure of three proteins from data collected at room ...
Petr Pachl +9 more
wiley +1 more source
Advanced Materials Interfaces, Volume 9, Issue 34, December 2, 2022., 2022 Laser‐induced graphene surfaces are hydrophobically modified to yield a superhydrophobic surface showing plastron formation under water. As a decay of the air layer is observed over time, plastron replenishment on a superhydrophobic laser‐induced graphene surface is achieved by Joule heating of the conductive surface. Abstract Superhydrophobic surfaces
Emily Manderfeld +4 more
wiley +1 more source