Results 41 to 50 of about 7,149,496 (277)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Dynamic coupling of nonlinear motion and unsteady aerodynamic load of helicopter bluff-body slung load

Xibei Gongye Daxue Xuebao
To analyze the dynamic coupling mechanisms between the nonlinear motion of a helicopter's bluff-body slung load and its unsteady aerodynamic load, and to further improve the prediction accuracy of coupling effects during the helicopter' slung load ...
MENG Xiaowei, WANG Luofeng, ZHANG Yunrui, ZHANG Honglin, CUI Zhao   +4 more
doaj   +1 more source

Definition in testing for the probability of exit of the aircraft in informational contact with air objects

Научный вестник МГТУ ГА, 2018
The article presents a methodology for determining the probability of aircraft information contacting airborne objects within flight test procedures.
S. V. Nikolaev, A. A. Tikhonov, D. S. Merencov   +2 more
doaj   +1 more source

Aircraft sensor fault detection based on temporal two-dimensionalization

Xibei Gongye Daxue Xuebao, 2023
Aerial sensor fault detection is of great importance in flight missions. However, the dimensionality of sensor time-series data is extremely high and the time span is extremely long, which lead to poor detection performance of existing methods.
ZHANG Da, GAO Junyu, DING Tenghuan, GU Shipeng, LI Xuelong   +4 more
doaj   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Mechanical and High-temperature Dielectric Properties of SiC_f/SiC Composites with SiO₂ Filler

Journal of Aeronautical Materials, 2018
The mechanical and high-temperature dielectric properties of SiCf/SiC composites with nano-SiO2 filler were investigated in the present work for the development of high-temperature structural microwave absorbing materials.
MU Yang, DENG Jiaxin, LI Hao, ZHOU Wancheng   +3 more
doaj   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Load Prediction of Digital Twin Logical Range in Space-Air-Ground Computing Power Networks Based on SSA-VMD [PDF]

Jisuanji gongcheng
In multitier space-air-ground computing power networks, the complexity and non-stationary characteristics of load data in a digital twin logical testbed hinder load data prediction accuracy.
CHEN Hao, DANG Zheng, HEI Xinhong, ZHAO Tong, ZHANG Jie
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Mapping the Social Network Structure and Composition of Black Individuals With Rheumatic and Musculoskeletal Conditions

Arthritis Care &Research, EarlyView.
Objective Our objective was to describe the social networks of Black individuals with rheumatic and musculoskeletal conditions and understand the clustering of health‐related behaviors to inform future community‐based, peer‐led interventions. Methods We used an adapted Personal Network Survey for Clinical Research (PERSNET) to map the personal social ...
Taussia Boadi, Amar Dhand, Leah Santacroce, Neil Pillai, Komel Safdar, Mia T. Chandler, Ariel Childs, Monica Crespo‐Bosque, Gina Curry, Mary Dollear, Alice Eggleston, Daniel Erickson, Dieufort Fleurissaint, Denice Garrett, Gail Granville, Tyler Green, Magdalena Hamielec, Elena Losina, Karen Mancera‐Cuevas, Mary Ann Nelson, Chisa Nosamiefan, Bisola Ojikutu, Tonya S. Roberson, Mary Beth Son, Marie Jacques Toussaint, Michael York, Rosalind Ramsey‐Goldman, Candace H. Feldman   +27 more
wiley   +1 more source