Results 131 to 140 of about 3,258 (217)

Age-related changes in lysosomal abundance in mouse hearts assessed by Lysotracker fluorescence imaging and autophagy gene expression analysis. [PDF]

Int J Cardiovasc Imaging
Albulushi J, Coghlan H, Moothanchery M, Dev A, Akerman E, Heenan J, Helassa N, Adegbite O, Sharma P, Patel F, Harrison L, Maguire ML, Mirams GR, Swietach P, Poptani H, Burton RA.   +15 more
europepmc   +1 more source

Time‐Dependent Bias and Prognostic Confounding in Exposure–Response Analysis of Targeted Therapies: Lessons from Sunitinib in Metastatic Renal Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure–response (E–R) analyses of sunitinib in metastatic renal cell carcinoma (mRCC) have supported concentration‐guided dose escalation. However, such analyses may be biased when exposure metrics incorporate post‐baseline dose modifications, time‐varying apparent clearance, or baseline factors that influence both pharmacokinetics and clinical ...
Han Liu, Lena E. Friberg
wiley   +1 more source

Regulation of Tmem30b-mediated apical membrane homeostasis in auditory outer hair cells is critical for hearing. [PDF]

Proc Natl Acad Sci U S A
Chang M, Hong G, Gao S, Cheng C, Yuan J, Xiao Y, Qiao R, Ke J, Wu X, Zhang T, Guo S, Jiang R, Liu Z, Zhou J, Zhang X, Wu Y, Zhao X, Li W, Shen S, He Z, Bi X, Chai R, Fu X.   +22 more
europepmc   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

ELSO 2025 Narrative Guideline on ECMO Training and Continuing Education. [PDF]

ASAIO J
Moore EA, Han P, Shekar K, Ramanathan K, Riera Del Brio J, Puslecki M, Diaz R, Alfoudri H, Ramanan R, Sin SWC, Vercaemst L, Friedrich T, Roeleveld P, Said A, Alinier G, Zakhary B.   +15 more
europepmc   +1 more source

Digital competencies in the EFL classroom: What is (or isn't) part of the curriculum for pre‐service primary EFL teachers at Spanish universities?

The Curriculum Journal, EarlyView.
Abstract The digital age has revolutionized many aspects of citizens' everyday lives, including educational systems, as Information and Communication Technologies (ICT) have been integrated into the curriculum at all educational levels. In the case of English as a foreign language (EFL), many studies support that ICTs contribute positively to the ...
María Felicidad Tabuenca Cuevas, Francisco Pradas Esteban, María Ribes Lafoz   +2 more
wiley   +1 more source

Re-exposition to ipilimumab plus nivolumab in metastatic Merkel cell carcinoma. [PDF]

Front Immunol
Glutsch V, Schummer P, Goebeler M, Gesierich A, Schilling B.   +4 more
europepmc   +1 more source

Population Pharmacokinetics and Detection Times of Betamethasone After Intravenous, Intramuscular, and Intranasal Jet Administration of Betamethasone Sodium Phosphate in Horses

Drug Testing and Analysis, EarlyView.
Betamethasone concentrations in 20 horses from Japan and Germany following IV, IM, and INJ administration of betamethasone phosphate were analyzed using population pharmacokinetic modeling. For IV administration of 0.04 mg/kg q24 h, IPC and IUC were 0.012 and 0.31 ng/mL, respectively; the IUC approximated the IFHA urine ISL (0.20 ng/mL).
Taisuke Kuroda, Marc Machnik, Mario Thevis, Yohei Minamijima, Gary Ngai‐Wa Leung, Motoi Nomura, Fumiaki Mizobe, Yuhiro Ishikawa, Kazuhiro Kamiya, Pierre‐Louis Toutain   +9 more
wiley   +1 more source

Dosimetric Performance Analysis of Pediatric Based Halcyon™ Volumetric Arc Therapy-Based Lung-Sparing Total Body Irradiation. [PDF]

Technol Cancer Res Treat
Haertter A, Goel K, Niculcea J, Li T, Hill-Kayser CE, Plastaras J, LaRiviere MJ, Kim MM.   +7 more
europepmc   +1 more source

Orthodentine‐osteodentine and osteocytic‐anosteocytic transition inferred from Silurian stem chondrichthyan dermal jawbones with ever‐white teeth overgrown by brown denticles

Developmental Dynamics, EarlyView.
Abstract Background The dentigerous jawbones of a 423‐million‐year‐old stem chondrichthyan (ischnacanthid acanthodian) carry a characteristic combination of multi‐row non‐shedding white teeth with brownish overgrowing denticles. The color distinction makes it a good model for observing the interaction between two odontode lineages, but the nature of ...
Jia‐Cih Kang, Henning Blom, Tiiu Märss, Donglei Chen   +3 more
wiley   +1 more source