Results 221 to 230 of about 17,770,023 (288)

Splenic Tropism and Spleen‐Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total‐body parasite biomass. Whether splenic tropism also occurs in acute infection and how the spleen influences pathogenesis have not been systematically explored. In Papua, Indonesia, we compared clinical and hematology data in 24 spleen‐intact and 25 previously
Steven Kho   +27 more
wiley   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

open access: yesAngewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray   +4 more
wiley   +2 more sources

Toward a Behavioral Reserve Model in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Neurology, EarlyView.
Objective Behavioral impairment is common in amyotrophic lateral sclerosis (ALS) and strongly affects autonomy, caregiver burden, and outcomes, yet predictors of vulnerability remain unclear. We investigated whether premorbid regulatory traits and socio‐educational exposures are associated with behavioral phenotypes in ALS within a behavioral reserve ...
Francesca Palumbo   +14 more
wiley   +1 more source

Titanium‐Catalyzed Defluorination of Poly(Vinyl Fluoride) and Poly(Vinylidene Fluoride) Under Friedel–Crafts Conditions

open access: yesAngewandte Chemie, EarlyView.
Cationic titanium sandwich catalysts display exceptional activity in the hydrodefluorination of Csp3─F bonds, in the presence of silanes and aromatic solvents (turnover numbers up to 3000). As a result, they can be used to defluorinate challenging fluoropolymers, such as poly(vinyl fluoride) (PVF) or poly(vinylidene fluoride) (PVDF).
Louis Le Moigne   +9 more
wiley   +2 more sources

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

open access: yesAnnals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes   +6 more
wiley   +1 more source

Synthesis of Ladder and Flexible Polysulfonimides Directly From Anionic Monomers: Investigating Structure–Property Convergence in Succinonitrile–Polymer Electrolyte Blends

open access: yesAngewandte Chemie, EarlyView.
Direct synthesis of sulfonimide‐based polymers of intrinsic microporosity enables comparison with compositionally similar flexible analogs. Incorporation of a common pore‐filling transport medium drives these fundamentally different polymer architectures toward similar bulk conductivity and mechanical properties while revealing distinct microscopic ion‐
Abraham Herzog‐Arbeitman   +8 more
wiley   +2 more sources

A Novel Sparse Cellular Labeling System with Tunable Gradients and Long-Term Stability. [PDF]

open access: yesAdv Sci (Weinh)
Tang X   +17 more
europepmc   +1 more source

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