Splenic Tropism and Spleen‐Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria
ABSTRACT In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total‐body parasite biomass. Whether splenic tropism also occurs in acute infection and how the spleen influences pathogenesis have not been systematically explored. In Papua, Indonesia, we compared clinical and hematology data in 24 spleen‐intact and 25 previously
Steven Kho +27 more
wiley +1 more source
Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray +4 more
wiley +2 more sources
Optimal Design of Large Aperture Primary Mirror of Spaceborne Solar EUV Imager Based on Optomechanical Coupling Analysis. [PDF]
Huang B, Li X, Li Z, Song K.
europepmc +1 more source
Toward a Behavioral Reserve Model in Amyotrophic Lateral Sclerosis
Objective Behavioral impairment is common in amyotrophic lateral sclerosis (ALS) and strongly affects autonomy, caregiver burden, and outcomes, yet predictors of vulnerability remain unclear. We investigated whether premorbid regulatory traits and socio‐educational exposures are associated with behavioral phenotypes in ALS within a behavioral reserve ...
Francesca Palumbo +14 more
wiley +1 more source
Cationic titanium sandwich catalysts display exceptional activity in the hydrodefluorination of Csp3─F bonds, in the presence of silanes and aromatic solvents (turnover numbers up to 3000). As a result, they can be used to defluorinate challenging fluoropolymers, such as poly(vinyl fluoride) (PVF) or poly(vinylidene fluoride) (PVDF).
Louis Le Moigne +9 more
wiley +2 more sources
Calcium-binding protein expression cannot serve as a general classifier for GABAergic neurons in macaque cortex. [PDF]
Brigande AM +3 more
europepmc +1 more source
T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes +6 more
wiley +1 more source
Direct synthesis of sulfonimide‐based polymers of intrinsic microporosity enables comparison with compositionally similar flexible analogs. Incorporation of a common pore‐filling transport medium drives these fundamentally different polymer architectures toward similar bulk conductivity and mechanical properties while revealing distinct microscopic ion‐
Abraham Herzog‐Arbeitman +8 more
wiley +2 more sources
A Novel Sparse Cellular Labeling System with Tunable Gradients and Long-Term Stability. [PDF]
Tang X +17 more
europepmc +1 more source
High-resolution energy data from a sustainable industrial production area in Karlsruhe. [PDF]
Sievers J, Bischof S, Blank T, Simon F.
europepmc +1 more source

