Results 91 to 100 of about 260,704 (325)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Whitefly-transmitted disease complex of the Desert Southwest

open access: yesCalifornia Agriculture, 1982
Crop losses caused by whitefly-transmitted agents could change the agriculture of the desert.
J Duffus, R Flock
doaj  

A strategic evaluation of the introduction of the East Friesian sheep breed on a North Island hill country farm : a thesis submitted in partial fulfilment of the requirements for the degree of Masters in Applied Science in Agricultural Systems and Management at Massey University [PDF]

open access: yes, 1998
New Zealand sheep fanning has changed dramatically over the past 20 years as it has adjusted to a market-led and unsubsidised economy. Despite this, new technology and management practices such as cross breeding offer exciting opportunities for improving
Martinez, Jesus Romero
core  

Modelling hierarchical flocking

open access: yesNew Journal of Physics, 2019
Abstract We present a general framework for modeling a wide selection of flocking scenarios under free boundary conditions. Several variants have been considered—including examples for the widely observed behavior of hierarchically interacting units. The models we have simulated correspond to classes of various realistic situations.
Yongnan Jia, Tamas Vicsek
openaire   +5 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Stability and Vulnerability of Bird Flocking Behaviour: A Mathematical Analysis

open access: yesHayati Journal of Biosciences, 2019
Given a large number of birds in the flock, we mathematically investigate the mechanism the birds move in a collective behavior. We assume that each bird is able to know its position and velocity of other birds within a radius of communication.
Bayu Erfianto, Intan Muchtadi-Alamsyah
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Field trials with the use of a live attenuated temperature-sensitive vaccine for the control of Mycoplasma gallisepticum infection in meat-type turkeys

open access: yesItalian Journal of Animal Science, 2010
Mycoplasma gallisepticum (MG) continues to be an important pathogen of poultry, causing significant production losses in many parts of the world. Eradication is the preferred method of control but it could result impractical after the organism has been ...
Mario Saita   +4 more
doaj   +1 more source

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