Results 81 to 90 of about 416,027 (334)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Comparative analysis of the local flora of Penza region

Известия высших учебных заведений. Поволжский регион: Естественные науки
Background. The analysis of local floras reveals floristic diversity in most detail. This component of biodiversity is basic for its study and is important for solving scientific and practical problems. Materials and methods.
Anastasia V. Ivanova, Natalya V. Kostina, Vladimir M. Vasjukov   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Fire-adapted Gondwanan Angiosperm floras evolved in the Cretaceous

BMC Evolutionary Biology, 2012
BackgroundFires have been widespread over the last 250 million years, peaking 60−125 million years ago (Ma), and might therefore have played a key role in the evolution of Angiosperms.
B. Lamont, Tianhua He
semanticscholar   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Update and reassessment of the Miocene carpological flora from the Turów open pit mine of SW Poland and its palaeoenvironmental implications

Acta Palaeobotanica
One of the largest and best known, but never completely investigated, fossil carpological floras of the Zittau Basin is revised. The list of revised taxa is supplemented with materials left by H. Czeczott and her team, and newly collected specimens.
Rafał Kowalski, Vasilis Teodoridis, Torsten Utescher   +2 more
doaj   +1 more source

Eocene–early Oligocene climate and vegetation change in southern China: Evidence from the Maoming Basin [PDF]

, 2017
Although the Eocene-Oligocene climate transition marks a critical point in the development of the ‘icehouse’ global climate of the present little is known about this important change in the terrestrial realm at low latitudes.
Aleksandrova, Galina N., Chen, Gang, Herman, Alexei B., Jin, Jian-Hua, Kodrul, Tatiana M., Maslova, Natalia P., Spicer, Robert A., Spicer, Teresa E.V., Yang, Jian   +8 more
core   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Plantas ornamentais no Jardim Botânico FLORAS

Paubrasilia, 2020
Um jardim botânico é um espaço que proporciona a conservação ex situ da biodiversidade, mantendo plantas vivas. O Jardim Botânico FLORAS (JBFLORAS) ocupa o campus Sosígenes Costa (CSC) da Universidade Federal do Sul da Bahia (UFSB) e possui um ...
Tainá Jardim Antunes, Cristiana Barros Nascimento Costa, Vinícius Castro Santos, Jorge Antonio Silva Costa   +3 more
doaj   +1 more source