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Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio +11 more
wiley +1 more source

DARI ENDE UNTUK INDONESIA: LAWATAN SEJARAH DAERAH SEBAGAI SUMBER BELAJAR BAGI GENERASI MUDA

Historia: Jurnal Pendidikan Sejarah FKIP UM Metro, 2018
Melemahnya rasa memiliki sejarah, belajar dari sejarah, dan kurangnya perhatian terhadap pengetahuan keberadaan objek-objek sejarah adalah rangkaian permasalahan kesejarahan dikalangan generasi muda.
Yohanes Yakobus Werang Kean +2 more
doaj +1 more source

A Global Prospective Harmonization Framework for Suicidality, Anhedonia, and Obsessive‐Compulsive Symptoms in Psychiatric Genetic Studies: A Cross‐Continental Study Within the Ancestral Population Network

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT This study aims to prospectively collect harmonized, quantitative, and dimensional psychiatric phenotypes (suicidality, anhedonia, and obsessive‐compulsive symptoms) and information on discrimination, stigma, and unfair treatment in up to 27,500 individuals across diverse ancestries and clinical populations for genetic analysis within the NIMH
Ana M. Diaz‐Zuluaga +36 more
wiley +1 more source

Numerical Study of MHD Hybrid Nanofluid Flow With Multiple Slip Effects Over a Variable Porous Stretching Surface

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT This work discusses the thermal performance of magnetized hybrid nanofluid flow over a variable porous stretchable surface, emphasizing the underlying physical mechanisms governing heat and mass transfer. The Cattaneo–Christov flux model is used in place of Fourier's and Fick's laws to incorporate relaxation effects, ensuring a more realistic ...
Mounirah Areshi +5 more
wiley +1 more source

Plasma–Kinetic Coupling and Redox Mechanisms in the Degradation of Acid Red 51 by Atmospheric Corona Discharge

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT This study investigates the degradation of the xanthene dye Acid Red 51 (ARE‐51) using atmospheric‐pressure corona discharge plasma, integrating electrical characterization, optical emission spectroscopy (OES), kinetic modeling, and physicochemical analysis to establish a unified plasma–liquid interaction framework. A degradation efficiency of
Cristian Mendoza Benítez +7 more
wiley +1 more source

A cost‐effective DNA extraction protocol for long‐read sequencing in non‐model plants

Applications in Plant Sciences, EarlyView.
Abstract Premise Third‐generation sequencing has revolutionized genomics, enabling in‐depth analysis of genome sequence, structure, and epigenetic features. Yet, extracting high‐quality DNA for long‐read sequencing remains a bottleneck—particularly in non‐model plants, such as mature trees growing in natural environments, which often contain abundant ...
Sofia Gaischuk +6 more
wiley +1 more source

Effects of intermittent exposure to hypobaria and cold on the microarchitecture and morphofunctional profile of rat gastrocnemius muscle

The Anatomical Record, EarlyView.
Abstract Intermittent hypobaric hypoxia (IHH) enhances oxygen transport, muscle metabolism, and cardiovascular health; however, the combined effects of hypobaria and cold are less well understood. Exposure to these stressful environmental factors, even intermittently, can affect skeletal muscle due to its plasticity, thereby altering its metabolic and ...
Garoa Santocildes +3 more
wiley +1 more source

QUALITY OF LIFE AND RESILIENCE OF PARENTS AND CAREGIVERS OF CHILDREN IN THE CHILDREN'S DEVELOPMENT CENTERS OF THE MINISTRY OF SOCIAL DEVELOPMENT OF THE GOVERNMENT OF THE CITY OF BUENOS AIRES

Revista Científica Arbitrada de la Fundación MenteClara
Based on the increase in the rates of social vulnerability of the Argentine population, an analysis was carried out regarding the quality of life and resilience of the population.
Bernardo Kerman +4 more
doaj +1 more source

Comparative cranial biomechanics reveal macroevolutionary trends in theropod dinosaurs, with emphasis on Tyrannosauroidea

The Anatomical Record, EarlyView.
Abstract Tyrannosaurus is viewed as a model organism in vertebrate paleontology, with numerous studies analyzing its feeding biomechanics. Nonetheless, the evolution of this feeding performance has been under‐addressed in Tyrannosauroidea, especially in basal tyrannosauroids. Here we used muscle‐force reconstruction and finite element analysis (FEA) to
Evan Johnson‐Ransom +4 more
wiley +1 more source

Improvements in Patient‐Reported Outcomes and Few Reported Major Complications Following Hip Arthroscopy in Patients With Femoroacetabular Impingement Syndrome: A Systematic Review

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To systematically review the literature to evaluate complications and patient‐reported outcome measures (PROMs) after hip arthroscopy in patients with femoroacetabular impingement syndrome. Methods Five databases were searched for studies reporting complications and PROMs after hip arthroscopy in patients with femoroacetabular impingement ...
Frederik Nicolai Foldager +6 more
wiley +1 more source