Results 191 to 200 of about 13,748 (211)

An Enzymatic Route to Florfenicol

Synthesis, 1991
Racemic ethyl threo-3-(4-methylthiophenyl)serinate is resolved by enzymatic hydrolysis using protease from Streptomyces griseus and both stereoisomers are converted to D-threo-4,5-dihydro-5-(4-methylsulfonylphenyl)-2-phenyl-4-oxazolemethanol, thereby giving a formal synthesis of ...
Jon E. Clark, Peter A. Fischer, Doris P. Schumacher   +2 more
openaire   +1 more source

An efficient synthesis of florfenicol

The Journal of Organic Chemistry, 1990
An efficient synthesis of florfenicol from commercially available starting materials has been achieved, using low cost and safe reagents.
Doris P. Schumacher, Jon E. Clark, Bruce L. Murphy, Peter A. Fischer   +3 more
openaire   +1 more source

Pharmacokinetics and tolerance of florfenicol in Equidae

Equine Veterinary Journal, 1996
Summary Florfenicol was administered to horses and ponies at a dose rate of 22 mg/kg bwt by i.v., i.m. and oral routes. Following i.v. administration it had an elimination half‐life of 1.8 ± 0.9 h, a body clearance of 0.4 ± 0.11/h.kg and a volume of distribution at steady‐state of 0.7 ± 0.2 1/kg. It was highly bioavailable following i.
Q A, McKellar, K J, Varma
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Use of florfenicol in non‐human primates

Journal of Medical Primatology, 2004
Abstract:  Studies were undertaken to determine if florfenicol, an antimicrobial agent structurally similar to chloramphenicol, could be used as an effective broad spectrum antibiotic for the treatment of bacterial infections in primates. Florfenicol was developed as an injectable antibiotic for use in cattle on an every other day dosing schedule.
Anthony L, Cook, Marisa, St Claire, Richard, Sams   +2 more
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Pharmacokinetics of florfenicol and thiamphenicol in ducks

Journal of Veterinary Pharmacology and Therapeutics, 2018
AbstractThe pharmacokinetics of florfenicol (FF) and thiamphenicol (TP) after single intravenous (IV) and oral (PO) administration was investigated in Mulard ducks. Both antibiotics were administered at a dose of 30 mg/kg body weight, and their concentrations in plasma samples were assayed using high‐performance liquid chromatography with ultraviolet ...
Marta Tikhomirov, Błażej Poźniak, Andrzej Smutkiewicz, Marcin Świtała   +3 more
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Depletion of florfenicol and florfenicol amine in eggs of laying hens and growing pullets after oral administration

Food Additives & Contaminants: Part A, 2020
In this study, we carried out two experiments to evaluate depletion of florfenicol (FF) and its metabolite florfenicol amine (FFA) in eggs from growing pullets and laying hens. Eggs were collected, and the egg white and yolk were separated. FF and FFA were analysed by liquid chromatography-tandem mass spectrometry.
Xia, Li, Lu, Chen, Hui, Yue, Hua, Feng, Enmin, Xu, Xiuli, Wei, Xiaoli, Han, Ligang, Deng, Zengmei, Li   +8 more
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Pharmacodynamics of florfenicol for calf pneumonia pathogens

Veterinary Record, 2013
The antimicrobial properties of florfenicol were investigated for the bovine respiratory tract pathogens, Mannheimia haemolytica and Pasteurella multocida . Three in vitro indices of efficacy and potency were determined; minimum inhibitory concentration
J Illambas, Timothy Potter, Pritam K. Sidhu, Andrew N. Rycroft, Zhangrui Cheng, P. Lees   +5 more
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Pharmacokinetics of florfenicol, thiamphenicol, and chloramphenicol in turkeys

Journal of Veterinary Pharmacology and Therapeutics, 2007
The pharmacokinetics of florfenicol (FF), thiamphenicol (TP) and chloramphenicol (CP) after single intravenous (i.v.) or oral (p.o.) administration was studied in an independent cross‐over study in broiler turkeys. All the fenicol antibiotics were administered at a dose of 30 mg/kg b.w.
M, Switała, R, Hrynyk, A, Smutkiewicz, K, Jaworski, P, Pawlowski, P, Okoniewski, T, Grabowski, J, Debowy   +7 more
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Nanoemulsion formulation of florfenicol improves bioavailability in pigs

Journal of Veterinary Pharmacology and Therapeutics, 2015
Nanotechnology applications in medicine have seen a tremendous growth in the past decade and are being employed to enhance the stability and bioavailability of lipophilic substances, such as florfenicol. This study aimed to examine the pharmacokinetic properties of the formulated oil‐in‐water florfenicol‐loaded nanoemulsion (FF‐NE).
Q, Zhang, S-S, Tang, M-Y, Qian, L, Wei, D, Zhou, Z-J, Zhang, J-K, He, Q-J, Zhang, P, Zhu, X-L, Xiao   +9 more
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Bioavailability and pharmacokinetics of florfenicol in healthy sheep*

Journal of Veterinary Pharmacology and Therapeutics, 2004
A study on bioavailability and pharmacokinetics of florfenicol was conducted in 20 crossbred healthy sheep following a single intravenous (i.v.) and intramuscular (i.m.) doses of 20 and 30 mg/kg body weight (b.w.). Florfenicol concentrations in serum were determined by a validated high‐performance liquid chromatography method with UV detection at a ...
Jianzhong, Shen, Xiubo, Li, Haiyang, Jiang, Walter H, Hsu, S, Jianzhong, L, Xiubo, J, Haiyang, H H, Walter   +7 more
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