Results 171 to 180 of about 22,941 (260)

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

open access: yesAdvanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu   +11 more
wiley   +1 more source

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

open access: yesAdvanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng   +12 more
wiley   +1 more source

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton

open access: yesAdvanced Science, EarlyView.
Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang   +32 more
wiley   +1 more source

2D Inorganic Electrides: Interstitial Electrons as Key Drivers of Multifunctional Properties and Applications

open access: yesAdvanced Science, EarlyView.
Eight AB‐type 2D inorganic electrides with negatively charged transition metals are theoretically designed. Their monolayers exhibit intrinsic magnetic ordering, rich topological phases, and ultralow work functions. Supported metal Ru on these 2D inorganic electrides effectively alleviates hydrogen poisoning and enables efficient ammonia synthesis ...
Qianwen Zhang   +6 more
wiley   +1 more source

An exciting Approach to Theoretical Spectroscopy

open access: yesAdvanced Science, EarlyView.
ABSTRACT Theoretical spectroscopy, and more generally, electronic‐structure theory, are powerful concepts for describing the complex many‐body interactions in materials. They cover methods from ground‐state properties to lattice excitations and light‐matter interaction, including time‐resolved variants.
Martí Raya‐Moreno   +29 more
wiley   +1 more source

Purification of Synthetic Gypsum: Techniques and Mechanisms. [PDF]

open access: yesMolecules
Wu C   +8 more
europepmc   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

open access: yesAdvanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu   +11 more
wiley   +1 more source

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