Advanced Science, EarlyView.Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen +6 more
wiley +1 more source
Efficient Flotation Separation of Ilmenite and Olivine in a Weak Alkaline Pulp Using a Ternary Combination Collector Centered around Al3. [PDF]
MoleculesLi J +6 more
europepmc +1 more source
Engineering Slow‐Carrier Interfacial Recombination Enables Tailored Spectral Response
Advanced Science, EarlyView.This work demonstrates that weak‐drift slow carriers are preferentially captured at generic semiconductor surfaces/interfaces and recombine. This process is manipulated to achieve tailored spectral response. A tens of µm‐wide depletion region is created to observe surface collection rates for photocarriers generated at different positions.
Yibo Zhang +5 more
wiley +1 more source
Flotation of silicon carbide from waste sludges [PDF]
"The Bureau of Mines conducted laboratory beneficiation tests on four samples of waste granite sludge to devise a method of recovering silicon carbide (sic).
core
Flotation separation of pyrite and carbonate minerals from a carlin-type gold deposit in Guizhou by a new combined collector and its adsorption mechanism. [PDF]
Sci RepZhu Z, Nie G, Deng Q, Tuo B, Qiu T.
europepmc +1 more source
Substrate Engineering of SWCNT p–n Junctions for Dual‐Mode Power Generation and Heat‐Flux Sensing
Advanced Science, EarlyView.Through substrate engineering alone, a single‐walled carbon nanotube p–n junction device switches between two functions under uniform infrared irradiation. A low‐absorbance substrate sustains a central hot junction for continuous power generation, whereas high‐absorbance substrates transiently invert the temperature gradient for sensitive heat‐flux ...
Ryota Tamai +3 more
wiley +1 more source
Study on synergistic inhibition and mechanism of flotation separation of fluorite and calcite by tannin and sodium humate. [PDF]
Sci RepZhu ZX +5 more
europepmc +1 more source
Differential Tissue‐Coupled Powering for Battery‐Free Injectable Electroceuticals
Advanced Science, EarlyView.A thread‐like injectable neural stimulator is powered through differential tissue‐coupled powering (DTCP), which harvests RF‐frequency tissue potentials with an elongated receiver while preserving a injectable cross‐section. The system integrates an ASIC, stimulation electrodes, and a portable transmitter, enabling wireless peripheral nerve stimulation,
Han Wu +13 more
wiley +1 more source
Advanced Science, EarlyView.An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei +10 more
wiley +1 more source
VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source